Effects of activation and blockade of dopamine D2 receptors on the immune response in mice with different types of behavior

被引：3
|
作者：
Idova G.V. [1 ]
Cheido M.A. [1 ]
Zhukova E.N. [1 ]
机构：
[1] State Research Institute of Physiology, Siberian Branch, Russian Academy of Medical Sciences, 630117 Novosibirsk
来源：
Neuroscience and Behavioral Physiology | 2007年 / 37卷 / 7期
基金：
俄罗斯基础研究基金会;
关键词：
Activation and blockade of D[!sub]2[!/sub] dopamine receptors; Aggressive and submissive behavior; Immune response; Psychoemotional state;
D O I：
10.1007/s11055-007-0074-8
中图分类号：
学科分类号：
摘要：
Activation of dopamine D2 receptors by the selective agonist quinpirole was found to lead to immunostimulation in control (no experience of confrontations) C57BL/6J mice and in mice subjected to psychoemotional tension (aggression and submission). The most marked increase in the immune response was seen on formation of the aggressive and submissive behavioral strategies. The effects of blockade of D2 dopamine receptors by haloperidol-immunosuppression-were seen only in control and aggressive animals, but were not seen in animals with submissive behavior. The question of the significance of the initial psychoemotional state, which is linked with particular neurotransmitter patterns in the brain (levels of dopamine, serotonin, their metabolites; dopamine receptor activity in subcortical structures), for the effects of agents altering the activity of dopamine D2 receptors on the immune response is discussed. © Springer Science+Business Media, Inc. 2007.
引用
收藏
页码：725 / 729
页数：4
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