Active Immunization of Humans with Dendritic Cells

被引：0
作者：
Madhav V. Dhodapkar
Nina Bhardwaj
机构：
[1] Rockefeller University,Laboratory of Cellular Physiology and Immunology
来源：
Journal of Clinical Immunology | 2000年 / 20卷
关键词：
Dendritic cells; immunotherapy; tumor immunology; antiviral immunity; cytolytic T cells;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Dendritic cells (DCs) are potent antigen-presenting cells specialized to initiate T-cell immunity. The development of methods to generate large numbers of DCs has facilitated their application for immunotherapy. Recent studies have demonstrated the safety and immunogenicity of DCs in humans and have begun to outline the durability, kinetics, and nature of the elicited T-cell responses. However, DC-based immunotherapy remains a challenge and several parameters need to be examined to optimize immune responses, in order to maximize clinical efficacy against cancer and infectious diseases.
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页码：167 / 174
页数：7
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[1]  
Raychaudhuri S(1998)Fully mobilizing host defense: Building better vaccines Nat Biotechnol 16 1025-1031
[2]  
Rock KL(1995)Principles for adoptive T cell therapy of human viral diseases Annu Rev Immunol 13 545-586
[3]  
Riddell SR(1999)Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease J Clin Oncol. 17 2639-2648
[4]  
Greenberg PD(1998)Dendritic cells and the control of immunity Nature 392 245-252
[5]  
Cobleigh MA(1996)Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells Nature Med 2 52-58
[6]  
Vogel CL(1998)Vaccination of melanoma patients with peptide-or tumor lysate-pulsed dendritic cells Nat Med 4 328-332
[7]  
Tripathy D(1996)Phase I clinical trial: T-cell therapy for prostate cancer using autologous dendritic cells pulsed with HLA-A020-specific peptides from prostate-specific peptides from prostate-specific membrane antigen Prostate 29 371-380
[8]  
Robert NJ(1999)Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells J Clin Invest 104 173-180
[9]  
Scholl S(2000)Mature dendritic cells boost functionally superior T cells in humans without foreign helper epitopes J Clin Invest 105 R9-R14
[10]  
Fehrenbacher L(1999)Generation of anti-idiotype immune responses following vaccination with idiotype-protein pulsed dendritic cells in myeloma Br J Haematol 107 648-655
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