Nonlinear relationship of insulin-like growth factor (IGF)-I and IGF-I/IGF-binding protein-3 ratio with indices of adiposity and plasma insulin concentrations (Sweden)

被引：0

作者：

Annekatrin Lukanova

Stefan Söderberg

Pär Stattin

Richard Palmqvist

Eva Lundin

Carine Biessy

Sabina Rinaldi

Elio Riboli

Göran Hallmans

Rudolf Kaaks

机构：

[1] International Agency for Research on Cancer,Department of Public Health and Clinical Medicine/Nutritional Research

[2] University of Umeå,Department of Nutrition and Cancer

[3] International Agency for Research on Cancer,University of Umeå, Department of Urology and Andrology and the Medical Biobank

[4] Northern Sweden University Hospital,Department of Pathology

[5] University of Umeå,Department of Medical Biosciences/Pathology, and Department of Public Health and Clinical Medicine/Nutritional Research

[6] University of Umeå,undefined

[7] International Agency for Research on Cancer,undefined

来源：

Cancer Causes & Control | 2002年 / 13卷

关键词：

body mass index; IGF-binding protein-3; IGF-I; insulin; leptin;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Objective: In this study we test the hypothesis of a nonlinear relationship of IGF-I with indices of body fat such as body mass index (BMI), insulin, and leptin. Methods: The controls used in three case–control cancer studies nested in the Northern Sweden Health and Disease Cohort, were combined for this analysis. Measurements of plasma IGF-I, IGFBP-3, insulin, and leptin were available for 445 men and 391 women. Results: In both men and women we found the highest mean IGF-I levels in subjects with BMI between 24 and 26. IGF-I concentrations decreased toward BMI ≤ 20 and BMI > 30 in men; however, the results for women did not reach statistical significance. The molar ratio of IGF-I/IGFBP-3 showed a similar profile to that of IGF-I, although much less pronounced. The observed peak mean IGF-I levels in the second quintiles of insulin and leptin in men supported these findings. No significant variation of mean IGF-I levels across quintiles of insulin and leptin were observed in women. Conclusions: The results of this study provide evidence that IGF-I plasma concentrations vary substantially over a wide range of body weight and that the relationship is nonlinear.

引用

页码：509 / 516

页数：7

共 160 条

[1] Hankinson SE(1998)Circulating concentrations of insulin-like growth factor-I and risk of breast cancer Lancet 351 1393-1396
[2] Willett WC(1993)Plasma insulinlike growth factor-1 (IGF-1) concentrations in human breast cancer Eur J Cancer 29A 492-497
[3] Colditz GA(2000)Serum Cpeptide, insulin-like growth factor (IGF)-I, IGF-binding proteins, and colorectal cancer risk in women J Natl Cancer Inst 92 1592-1600
[4] Peyrat JP(1999)Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3 J Natl Cancer Inst 91 620-625
[5] Bonneterre J(2000)Plasma insulin-like growth factor-I, insulin-like growth factor-binding proteins, and prostate cancer risk: a prospective study J Natl Cancer Inst 92 1910-1917
[6] Hecquet B(1998)Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study Science 279 563-566
[7] Kaaks R(1991)Nutritional regulation of IGF-I and IGF binding proteins Annu Rev Nutr 11 393-412
[8] Toniolo P(2001)Energy balance and cancer: the role of insulin and insulin-like growth factor-I Proc Nutr Soc 60 91-106
[9] Akhmedkhanov A(1997)Multiple endocrine abnormalities of the growth hormone and insulin-like growth factor axis in patients with anorexia nervosa: effect of short-and long-term weight recuperation J Clin Endocrinol Metab 82 2084-2092
[10] Ma J(1993)Serum insulin-like growth factor-I concentrations in the recovery of patients with anorexia nervosa J Am Coll Nutr 12 475-478

← 1 2 3 4 5 6 7 8 9 10 →