Thermoanalytical studies on complexes of furosemide with β-cyclodextrin derivatives

被引：0

作者：

Amin Kreaz R.M. ^{[1
]}

Novák Cs. ^{[2
]}

Erös I. ^{[2
]}

Kata M. ^{[1
]}

机构：

[1] Dept. of Pharmaceutical Technology, Szent-Györgyi Albert Med. Univ., H-6701 Szeged

[2] Inst. of Gen. and Analyt. Chemistry, Technical University of Budapest, H-1521 Budapest

来源：

Journal of Thermal Analysis and Calorimetry | 1999年 / 55卷 / 1期

关键词：

Furosemide; HP-β-CD; RAMEB; Thermal analysis;

D O I：

10.1023/A:1010188206790

中图分类号：

学科分类号：

摘要：

Solid formulas obtained between furosemide and two β-cyclodextrin derivatives (HP-β-CD and RAMEB) were prepared by different methods and in various ratios (1:1 and 1:2). The inclusion complex formation between the drug and the β-CDs of 1:1 ratio was evaluated by mean of thermal analysis (DSC, TG and EGD). Supplementary techniques, such as X-ray diffraction, were also applied to interpret the results of the thermal study of physically mixed and kneaded products. Both studies demonstrated the formation of inclusion complexes in all samples except the physical mix samples; formation of true inclusion complexes was then possible only when the components were in melted form. The complexation increased the solubility and the rate of dissolution of the drug. RAMEB was found to be a better complexing agent than HP-β-CD; in both ratios it can be selected as a vehicle in furosemide tablet preparations.

引用

页码：115 / 122

页数：7

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