Epistasis as the primary factor in molecular evolution

被引：0
作者：
Michael S. Breen
Carsten Kemena
Peter K. Vlasov
Cedric Notredame
Fyodor A. Kondrashov
机构：
[1] Bioinformatics and Genomics Programme,
[2] Centre for Genomic Regulation and Universitat Pompeu Fabra,undefined
[3] 88 Dr Aiguader,undefined
[4] Barcelona 08003,undefined
[5] Spain,undefined
[6] Institució Catalana de Recerca i Estudis Avançats (ICREA),undefined
[7] 23 Passeig Lluís Companys,undefined
来源：
Nature | 2012年 / 490卷
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摘要：
A comparison of more than 1,000 orthologues of diverse proteins shows that the rate of amino-acid substitution in recent evolution is an order of magnitude lower than that expected in the absence of epistasis, indicating that epistasis is pervasive throughout protein evolution.
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页码：535 / 538
页数：3
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