Resequencing and mutational analysis using oligonucleotide microarrays

被引:0
|
作者
Joseph G. Hacia
机构
[1] Genetics and Molecular Biology Branch,
[2] National Human Genome Research Institute,undefined
来源
Nature Genetics | 1999年 / 21卷
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摘要
Oligonucleotide microarray (DNA chip)–based hybridization analysis is a promising new technology which potentially allows rapid and cost–effective screens for all possible mutations and sequence variations in genomic DNA. Here, I review current strategies and uses for DNA chip–based resequencing and mutational analysis, the underlying principles of experimental designs, and future efforts to improve the sensitivity and specificity of chip–based assays.
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页码:42 / 47
页数:5
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