The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes

被引：0

作者：

Anna-Barbara Stittrich

Claudia Haftmann

Evridiki Sgouroudis

Anja Andrea Kühl

Ahmed Nabil Hegazy

Isabel Panse

Rene Riedel

Michael Flossdorf

Jun Dong

Franziska Fuhrmann

Gitta Anne Heinz

Zhuo Fang

Na Li

Ute Bissels

Farahnaz Hatam

Angelina Jahn

Ben Hammoud

Mareen Matz

Felix-Michael Schulze

Ria Baumgrass

Andreas Bosio

Hans-Joachim Mollenkopf

Joachim Grün

Andreas Thiel

Wei Chen

Thomas Höfer

Christoph Loddenkemper

Max Löhning

Hyun-Dong Chang

Nikolaus Rajewsky

Andreas Radbruch

Mir-Farzin Mashreghi

机构：

[1] Deutsches Rheuma-Forschungszentrum Berlin,Department of Rheumatology and Clinical Immunology

[2] Charité Research Center for ImmunoSciences–Institute of Pathology,Department of Nephrology

[3] Charité Universitätsmedizin Berlin,Department of Immunology

[4] Campus Benjamin Franklin,undefined

[5] Experimental Immunology,undefined

[6] Charité Universitätsmedizin Berlin,undefined

[7] Campus Charité Mitte,undefined

[8] German Cancer Research Center (Deutsches Krebsforschungszentrum),undefined

[9] Berlin-Brandenburg Center for Regenerative Therapies,undefined

[10] Charité Universitätsmedizin Berlin,undefined

[11] Campus Virchow-Klinikum,undefined

[12] Robert Koch Institute,undefined

[13] Max-Delbrück-Center for Molecular Medicine,undefined

[14] Miltenyi Biotec,undefined

[15] Germany,undefined

[16] Charité Universitätsmedizin Berlin,undefined

[17] Campus Charité Mitte,undefined

[18] Institut für Immunologie und Transfusionsmedizin,undefined

[19] Universität Greifswald,undefined

[20] Max Planck Institute for Infection Biology,undefined

来源：

Nature Immunology | 2010年 / 11卷

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摘要：

Clonal expansion of helper T lymphocytes initially requires inactivation of the transcription factor Foxo1 by post-translational modifications. Mashreghi and colleagues now show in the late phase of clonal expansion, Foxo1 is inhibited post-transcriptionally by the microRNA miR-182.

引用

页码：1057 / 1062

页数：5

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[1] The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes
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