Effect of Boswellia serrata supplementation on blood lipid, hepatic enzymes and fructosamine levels in type2 diabetic patients

被引：37
作者：
Ahangarpour A. [1 ]
Heidari H. [2 ,3 ]
Fatemeh R.A.A. [4 ]
Pakmehr M. [5 ]
Shahbazian H. [6 ]
Ahmadi I. [4 ]
Mombeini Z. [5 ]
Mehrangiz B.H. [5 ]
机构：
[1] Diabetes Research Center, School of Medicine, Health research institute and Department of Physiology, Jundishapur University of Medical Sciences, Golestan Street, Ahvaz
[2] Department of Physiology, School of Medicine, Jundishapur University of Medical Sciences, Golestan Street, Ahvaz
[3] Department of Physiology, School of Medicine, Qom University of Medical Sciences, Saheli Street, Qom
[4] Physiology Research Center, Dept of Physiology, School of Medicine, Member of Student Research Committee of Ahvaz Jundishapur University of Medical Sciences, Golestan Street, Ahvaz
[5] Student Research Committee of Ahvaz Jundishapur University of Medical Science, School of Medicine, Golestan Street, Ahvaz
[6] Diabetes Research Center, Health research institute, School of Medicine, Jundishapur Medical Sciences University of Ahvaz, Golestan Street, Ahvaz
来源：
Journal of Diabetes & Metabolic Disorders | / 13卷 / 1期
关键词：
Boswellia serrata; Diabetes; Fructosamine; Lipid profiles;
D O I：
10.1186/2251-6581-13-29
中图分类号：
学科分类号：
摘要：
Background: Type 2 diabetes is an endocrine disorder that affects a large percentage of patients. High blood glucose causes fatty deposits in the liver which is likely to increase in SGOT and SGPT activities. Significant increase in SGOT/SGPT and low HDL levels is observed in patients with diabetes. Serum fructosamine concentration reflects the degree of blood glucose control in diabetic patients. This study was aimed to investigate the antidiabetic, hypolipidemic and hepatoprotective effects of supplementation of Boswellia serrata in type2 diabetic patients.Methods: 60 type 2 diabetic patients from both sexes (30 males and 30 females) were dedicated to the control and intervention groups (30 subjects per group). Boswellia serrata gum resin in amount of 900 mg daily for 6 weeks were orally administered (as three 300 mg doses) in intervention group and the control group did not receive anything. Blood samples were taken at the beginning of the study and after 6 weeks. Blood levels of fructosamine, lipid profiles as well as hepatic enzyme in type 2 diabetic patients were measured.Results: Treatment of diabetic patient with Boswellia serrata was caused to significant increase in blood HDL levels as well as a remarkable decrease in cholesterol, LDL, fructosamine (p < 0.05) SGPT and SGOT levels after 6 weeks (p < 0.01). In spite of reduction of serum triglyceride, VLDL levels in intervention group, we did not detect a significant difference after 6 weeks.Conclusion: This study showed that Boswellia serrata supplementation can be beneficial in controlling blood parameters in patients with type 2 diabetes. Therefore, its use can be useful in patients with medicines. © 2014 Ahangarpour et al.; licensee BioMed Central Ltd.
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