New Approaches for Tailoring the Use of Radiotherapy in Early-Stage Breast Cancer

被引：0

作者：

White J. ^{[1
]}

机构：

[1] Department of Radiation Oncology, Stefanie Spielman Comprehensive Breast Center, The James, Ohio State University Comprehensive Cancer Center, 1145 Olentangy River Rd, Columbus, 43212, OH

来源：

Current Breast Cancer Reports | 2017年 / 9卷 / 2期

关键词：

Breast cancer; Intrinsic subtypes; Multigene assays; Radiotherapy;

D O I：

10.1007/s12609-017-0240-0

中图分类号：

学科分类号：

摘要：

Purpose of Review: The majority of women diagnosed with early-stage breast cancer will undergo radiotherapy. Clinical decisions regarding the delivery of radiotherapy are typically based on clinical and pathologic factors. In contrast, systemic therapy clinical decisions incorporate specific breast cancer biology. This review will focus on how breast cancer biology may help tailor radiotherapy for early-stage patients. Recent Findings: Radiotherapy for early-stage breast cancer is typically delivered for breast conservation. Regional nodal radiotherapy use in early-stage disease is expected to expand in the wake of recent clinical trial publications demonstrating improved disease-free survival in those with one to three axillary nodal metastases. There is a growing body of data demonstrating that intrinsic breast cancer subtypes and luminal multigene assays developed for systemic therapy are also associated with local regional recurrence. Summary: Including tumor biology in addition to standard clinical and pathological factors may lead to a more tailored use of radiotherapy in early-stage breast cancer. © 2017, Springer Science+Business Media New York.

引用

页码：129 / 136

页数：7

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