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- [1] Unique functions of CHK1 and WEE1 underlie synergistic anti-tumor activity upon pharmacologic inhibitionCANCER CELL INTERNATIONAL, 2012, 12Guertin, Amy D.论文数: 0 引用数: 0 h-index: 0机构: Merck Res Labs, Dept Oncol, Boston, MA 02115 USA Merck Res Labs, Dept Oncol, Boston, MA 02115 USAMartin, Melissa M.论文数: 0 引用数: 0 h-index: 0机构: Amgen Inc, Thousand Oaks, CA 91320 USA Merck Res Labs, Dept Oncol, Boston, MA 02115 USARoberts, Brian论文数: 0 引用数: 0 h-index: 0机构: Hudson Alpha Inst, Huntsville, AL 35801 USA Merck Res Labs, Dept Oncol, Boston, MA 02115 USAHurd, Melissa论文数: 0 引用数: 0 h-index: 0机构: Merck Res Labs, Dept Vivo Pharmacol, Boston, MA 02115 USA Merck Res Labs, Dept Oncol, Boston, MA 02115 USAQu, Xianlu论文数: 0 引用数: 0 h-index: 0机构: Merck Res Labs, Mol Biomarkers, Boston, MA 02115 USA Merck Res Labs, Dept Oncol, Boston, MA 02115 USAMiselis, Nathan R.论文数: 0 引用数: 0 h-index: 0机构: Merck Res Labs, Mol Biomarkers, Boston, MA 02115 USA Merck Res Labs, Dept Oncol, Boston, MA 02115 USALiu, Yaping论文数: 0 引用数: 0 h-index: 0机构: Merck Res Labs, Screening & Prot Sci, N Wales, PA 19454 USA Merck Res Labs, Dept Oncol, Boston, MA 02115 USALi, Jing论文数: 0 引用数: 0 h-index: 0机构: Merck Res Labs, Screening & Prot Sci, N Wales, PA 19454 USA Merck Res Labs, Dept Oncol, Boston, MA 02115 USAFeldman, Igor论文数: 0 引用数: 0 h-index: 0机构: Merck Res Labs, Informat & Anal, Boston, MA 02115 USA Merck Res Labs, Dept Oncol, Boston, MA 02115 USABenita, Yair论文数: 0 引用数: 0 h-index: 0机构: Merck Res Labs, Informat & Anal, Boston, MA 02115 USA Merck Res Labs, Dept Oncol, Boston, MA 02115 USABloecher, Andrew论文数: 0 引用数: 0 h-index: 0机构: Merck Res Labs, Dept Oncol, Boston, MA 02115 USA Merck Res Labs, Dept Oncol, Boston, MA 02115 USAToniatti, Carlo论文数: 0 引用数: 0 h-index: 0机构: Inst Appl Canc Sci, Houston, TX 77054 USA Merck Res Labs, Dept Oncol, Boston, MA 02115 USAShumway, Stuart D.论文数: 0 引用数: 0 h-index: 0机构: Merck Res Labs, Dept Oncol, Boston, MA 02115 USA Merck Res Labs, Dept Oncol, Boston, MA 02115 USA
- [2] Combined inhibition of Chk1 and Wee1 In vitro synergistic effect translates to tumor growth inhibition in vivoCELL CYCLE, 2012, 11 (13) : 2507 - 2517Carrassa, Laura论文数: 0 引用数: 0 h-index: 0机构: Ist Ric Farmacol Mario Negri, Dept Oncol, Mol Pharmacol Lab, Milan, Italy Ist Ric Farmacol Mario Negri, Dept Oncol, Mol Pharmacol Lab, Milan, ItalyChila, Rosaria论文数: 0 引用数: 0 h-index: 0机构: Ist Ric Farmacol Mario Negri, Dept Oncol, Mol Pharmacol Lab, Milan, Italy Ist Ric Farmacol Mario Negri, Dept Oncol, Mol Pharmacol Lab, Milan, ItalyLupi, Monica论文数: 0 引用数: 0 h-index: 0机构: Ist Ric Farmacol Mario Negri, Dept Oncol, Lab Canc Pharmacol, Milan, Italy Ist Ric Farmacol Mario Negri, Dept Oncol, Mol Pharmacol Lab, Milan, ItalyRicci, Francesca论文数: 0 引用数: 0 h-index: 0机构: Ist Ric Farmacol Mario Negri, Dept Oncol, Mol Pharmacol Lab, Milan, Italy Ist Ric Farmacol Mario Negri, Dept Oncol, Mol Pharmacol Lab, Milan, ItalyCelenza, Cinzia论文数: 0 引用数: 0 h-index: 0机构: Ist Ric Farmacol Mario Negri, Dept Oncol, Mol Pharmacol Lab, Milan, Italy Ist Ric Farmacol Mario Negri, Dept Oncol, Mol Pharmacol Lab, Milan, ItalyMazzoletti, Marco论文数: 0 引用数: 0 h-index: 0机构: Ist Ric Farmacol Mario Negri, Dept Oncol, Mol Pharmacol Lab, Milan, Italy Ist Ric Farmacol Mario Negri, Dept Oncol, Mol Pharmacol Lab, Milan, ItalyBroggini, Massimo论文数: 0 引用数: 0 h-index: 0机构: Ist Ric Farmacol Mario Negri, Dept Oncol, Mol Pharmacol Lab, Milan, Italy Ist Ric Farmacol Mario Negri, Dept Oncol, Mol Pharmacol Lab, Milan, ItalyDamia, Giovanna论文数: 0 引用数: 0 h-index: 0机构: Ist Ric Farmacol Mario Negri, Dept Oncol, Mol Pharmacol Lab, Milan, Italy Ist Ric Farmacol Mario Negri, Dept Oncol, Mol Pharmacol Lab, Milan, Italy
- [3] CASC-578, a novel Chk1 inhibitor, is active as a single agent in solid tumors and displays synergistic anti-tumor activity in combination with Wee1 inhibitionCANCER RESEARCH, 2017, 77Vo, Alex论文数: 0 引用数: 0 h-index: 0Taylor, Janelle论文数: 0 引用数: 0 h-index: 0Rosler, Robert论文数: 0 引用数: 0 h-index: 0Piasecki, Julia论文数: 0 引用数: 0 h-index: 0Leviten, Dina论文数: 0 引用数: 0 h-index: 0Sierra, Teresa论文数: 0 引用数: 0 h-index: 0Dozier, Ashley论文数: 0 引用数: 0 h-index: 0Klucher, Kevin论文数: 0 引用数: 0 h-index: 0Boyle, Bob论文数: 0 引用数: 0 h-index: 0Boyce, Rich论文数: 0 引用数: 0 h-index: 0Peterson, Scott论文数: 0 引用数: 0 h-index: 0
- [4] Combined inhibition of Chk1 and Wee1 kinases for cancer treatmentRADIOTHERAPY AND ONCOLOGY, 2016, 119 : S478 - S478Hauge, S.论文数: 0 引用数: 0 h-index: 0机构: DNR Norwegian Radium Hosp, Dept Radiat Biol, Oslo, Norway DNR Norwegian Radium Hosp, Dept Radiat Biol, Oslo, NorwayHasvold, G.论文数: 0 引用数: 0 h-index: 0机构: DNR Norwegian Radium Hosp, Dept Radiat Biol, Oslo, Norway DNR Norwegian Radium Hosp, Dept Radiat Biol, Oslo, NorwayJoel, M.论文数: 0 引用数: 0 h-index: 0机构: DNR Norwegian Radium Hosp, Dept Radiat Biol, Oslo, Norway DNR Norwegian Radium Hosp, Dept Radiat Biol, Oslo, NorwayNaucke, C.论文数: 0 引用数: 0 h-index: 0机构: DNR Norwegian Radium Hosp, Dept Radiat Biol, Oslo, Norway DNR Norwegian Radium Hosp, Dept Radiat Biol, Oslo, NorwayRodland, G. E.论文数: 0 引用数: 0 h-index: 0机构: DNR Norwegian Radium Hosp, Dept Radiat Biol, Oslo, Norway DNR Norwegian Radium Hosp, Dept Radiat Biol, Oslo, NorwaySyljuasen, R. G.论文数: 0 引用数: 0 h-index: 0机构: DNR Norwegian Radium Hosp, Dept Radiat Biol, Oslo, Norway DNR Norwegian Radium Hosp, Dept Radiat Biol, Oslo, Norway
- [5] Chk1 inhibition and Wee1 inhibition combine synergistically to impede cellular proliferationCANCER BIOLOGY & THERAPY, 2011, 12 (09) : 788 - 796Davies, Kurtis D.论文数: 0 引用数: 0 h-index: 0机构: Array BioPharma Inc, Cell Biol, Boulder, CO USA Array BioPharma Inc, Cell Biol, Boulder, CO USACable, P. LouAnn论文数: 0 引用数: 0 h-index: 0机构: Array BioPharma Inc, Translat Biol, Boulder, CO USA Array BioPharma Inc, Cell Biol, Boulder, CO USAGarrus, Jennifer E.论文数: 0 引用数: 0 h-index: 0机构: Array BioPharma Inc, Translat Biol, Boulder, CO USA Array BioPharma Inc, Cell Biol, Boulder, CO USASullivan, Francis X.论文数: 0 引用数: 0 h-index: 0机构: Array BioPharma Inc, Enzymol, Boulder, CO USA Array BioPharma Inc, Cell Biol, Boulder, CO USAvon Carlowitz, Ira论文数: 0 引用数: 0 h-index: 0机构: Array BioPharma Inc, Cell Biol, Boulder, CO USA Array BioPharma Inc, Cell Biol, Boulder, CO USALe Huerou, Yvan论文数: 0 引用数: 0 h-index: 0机构: Array BioPharma Inc, Chem, Boulder, CO USA Array BioPharma Inc, Cell Biol, Boulder, CO USAWallace, Eli论文数: 0 引用数: 0 h-index: 0机构: Array BioPharma Inc, Chem, Boulder, CO USA Array BioPharma Inc, Cell Biol, Boulder, CO USAWoessner, Richard D.论文数: 0 引用数: 0 h-index: 0机构: Array BioPharma Inc, Cell Biol, Boulder, CO USA Array BioPharma Inc, Cell Biol, Boulder, CO USAGross, Stefan论文数: 0 引用数: 0 h-index: 0机构: Array BioPharma Inc, Cell Biol, Boulder, CO USA Array BioPharma Inc, Cell Biol, Boulder, CO USA
- [6] Combined inhibition of Wee1 and Chk1 as a therapeutic strategy in multiple myelomaFRONTIERS IN ONCOLOGY, 2023, 13Bruyer, Angelique论文数: 0 引用数: 0 h-index: 0机构: Diag2Tec, Montpellier, France Diag2Tec, Montpellier, FranceDutrieux, Laure论文数: 0 引用数: 0 h-index: 0机构: Inst Human Genet, UMR UM 9002, CNRS, Montpellier, France Diag2Tec, Montpellier, Francede Boussac, Hugues论文数: 0 引用数: 0 h-index: 0机构: Diag2Tec, Montpellier, France Diag2Tec, Montpellier, FranceMartin, Thibaut论文数: 0 引用数: 0 h-index: 0机构: Inst Human Genet, UMR UM 9002, CNRS, Montpellier, France Diag2Tec, Montpellier, FranceChemlal, Djamila论文数: 0 引用数: 0 h-index: 0机构: Diag2Tec, Montpellier, France Inst Human Genet, UMR UM 9002, CNRS, Montpellier, France Diag2Tec, Montpellier, FranceRobert, Nicolas论文数: 0 引用数: 0 h-index: 0机构: CHU Montpellier, Dept Biol Hematol, Montpellier, France Diag2Tec, Montpellier, FranceRequirand, Guilhem论文数: 0 引用数: 0 h-index: 0机构: CHU Montpellier, Dept Biol Hematol, Montpellier, France Diag2Tec, Montpellier, France论文数: 引用数: h-index:机构:Vincent, Laure论文数: 0 引用数: 0 h-index: 0机构: CHU Montpellier, Dept Clin Hematol, Montpellier, France Diag2Tec, Montpellier, FranceHerbaux, Charles论文数: 0 引用数: 0 h-index: 0机构: Inst Human Genet, UMR UM 9002, CNRS, Montpellier, France CHU Montpellier, Dept Clin Hematol, Montpellier, France Univ Montpellier, UFR Med, Montpellier, France Diag2Tec, Montpellier, FranceLutzmann, Malik论文数: 0 引用数: 0 h-index: 0机构: Inst Human Genet, UMR UM 9002, CNRS, Montpellier, France Diag2Tec, Montpellier, FranceBret, Caroline论文数: 0 引用数: 0 h-index: 0机构: Inst Human Genet, UMR UM 9002, CNRS, Montpellier, France CHU Montpellier, Dept Biol Hematol, Montpellier, France Univ Montpellier, UFR Med, Montpellier, France Diag2Tec, Montpellier, FrancePasero, Philippe论文数: 0 引用数: 0 h-index: 0机构: Inst Human Genet, UMR UM 9002, CNRS, Montpellier, France Diag2Tec, Montpellier, France论文数: 引用数: h-index:机构:Ovejero, Sara论文数: 0 引用数: 0 h-index: 0机构: Inst Human Genet, UMR UM 9002, CNRS, Montpellier, France CHU Montpellier, Dept Biol Hematol, Montpellier, France Diag2Tec, Montpellier, France
- [7] Chk1 inhibition and Wee1 inhibition combine synergistically to inhibit cellular proliferationCANCER RESEARCH, 2011, 71Davies, Kurtis D.论文数: 0 引用数: 0 h-index: 0机构: Array Biopharma Inc, Boulder, CO USA Array Biopharma Inc, Boulder, CO USASullivan, Francis论文数: 0 引用数: 0 h-index: 0机构: Array Biopharma Inc, Boulder, CO USA Array Biopharma Inc, Boulder, CO USAvon Carlowitz, Ira论文数: 0 引用数: 0 h-index: 0机构: Array Biopharma Inc, Boulder, CO USA Array Biopharma Inc, Boulder, CO USALe Huerou, Yvan论文数: 0 引用数: 0 h-index: 0机构: Array Biopharma Inc, Boulder, CO USA Array Biopharma Inc, Boulder, CO USAWallace, Eli论文数: 0 引用数: 0 h-index: 0机构: Array Biopharma Inc, Boulder, CO USA Array Biopharma Inc, Boulder, CO USAWoessner, Richard D.论文数: 0 引用数: 0 h-index: 0机构: Array Biopharma Inc, Boulder, CO USA Array Biopharma Inc, Boulder, CO USAGross, Stefan论文数: 0 引用数: 0 h-index: 0机构: Array Biopharma Inc, Boulder, CO USA Array Biopharma Inc, Boulder, CO USA
- [8] Synergism Through WEE1 and CHK1 Inhibition in Acute Lymphoblastic LeukemiaCANCERS, 2019, 11 (11)Di Rora, Andrea Ghelli Luserna论文数: 0 引用数: 0 h-index: 0机构: IRCCS, Ist Scientif Romagnolo Studio & Cura Tumori IRST, I-47014 Meldola, Italy IRCCS, Ist Scientif Romagnolo Studio & Cura Tumori IRST, I-47014 Meldola, ItalyBocconcelli, Matteo论文数: 0 引用数: 0 h-index: 0机构: Univ Bologna, Inst Hematol LeA Seragnoli, Dept Expt Diagnost & Specialty Med, I-40138 Bologna, Italy IRCCS, Ist Scientif Romagnolo Studio & Cura Tumori IRST, I-47014 Meldola, ItalyFerrari, Anna论文数: 0 引用数: 0 h-index: 0机构: IRCCS, Ist Scientif Romagnolo Studio & Cura Tumori IRST, I-47014 Meldola, Italy IRCCS, Ist Scientif Romagnolo Studio & Cura Tumori IRST, I-47014 Meldola, ItalyTerragna, Carolina论文数: 0 引用数: 0 h-index: 0机构: Univ Bologna, Inst Hematol LeA Seragnoli, Dept Expt Diagnost & Specialty Med, I-40138 Bologna, Italy IRCCS, Ist Scientif Romagnolo Studio & Cura Tumori IRST, I-47014 Meldola, ItalyBruno, Samantha论文数: 0 引用数: 0 h-index: 0机构: Univ Bologna, Inst Hematol LeA Seragnoli, Dept Expt Diagnost & Specialty Med, I-40138 Bologna, Italy IRCCS, Ist Scientif Romagnolo Studio & Cura Tumori IRST, I-47014 Meldola, ItalyImbrogno, Enrica论文数: 0 引用数: 0 h-index: 0机构: IRCCS, Ist Scientif Romagnolo Studio & Cura Tumori IRST, I-47014 Meldola, Italy IRCCS, Ist Scientif Romagnolo Studio & Cura Tumori IRST, I-47014 Meldola, ItalyBeeharry, Neil论文数: 0 引用数: 0 h-index: 0机构: AI Therapeut, Guilford, CT 06437 USA IRCCS, Ist Scientif Romagnolo Studio & Cura Tumori IRST, I-47014 Meldola, ItalyRobustelli, Valentina论文数: 0 引用数: 0 h-index: 0机构: Univ Bologna, Inst Hematol LeA Seragnoli, Dept Expt Diagnost & Specialty Med, I-40138 Bologna, Italy IRCCS, Ist Scientif Romagnolo Studio & Cura Tumori IRST, I-47014 Meldola, ItalyGhetti, Martina论文数: 0 引用数: 0 h-index: 0机构: IRCCS, Ist Scientif Romagnolo Studio & Cura Tumori IRST, I-47014 Meldola, Italy IRCCS, Ist Scientif Romagnolo Studio & Cura Tumori IRST, I-47014 Meldola, ItalyNapolitano, Roberta论文数: 0 引用数: 0 h-index: 0机构: IRCCS, Ist Scientif Romagnolo Studio & Cura Tumori IRST, I-47014 Meldola, Italy IRCCS, Ist Scientif Romagnolo Studio & Cura Tumori IRST, I-47014 Meldola, ItalyChirumbolo, Gabriella论文数: 0 引用数: 0 h-index: 0机构: Univ Bologna, Inst Hematol LeA Seragnoli, Dept Expt Diagnost & Specialty Med, I-40138 Bologna, Italy IRCCS, Ist Scientif Romagnolo Studio & Cura Tumori IRST, I-47014 Meldola, ItalyMarconi, Giovanni论文数: 0 引用数: 0 h-index: 0机构: Univ Bologna, Inst Hematol LeA Seragnoli, Dept Expt Diagnost & Specialty Med, I-40138 Bologna, Italy IRCCS, Ist Scientif Romagnolo Studio & Cura Tumori IRST, I-47014 Meldola, Italy论文数: 引用数: h-index:机构:论文数: 引用数: h-index:机构:Sartor, Chiara论文数: 0 引用数: 0 h-index: 0机构: Univ Bologna, Inst Hematol LeA Seragnoli, Dept Expt Diagnost & Specialty Med, I-40138 Bologna, Italy IRCCS, Ist Scientif Romagnolo Studio & Cura Tumori IRST, I-47014 Meldola, ItalySimonetti, Giorgia论文数: 0 引用数: 0 h-index: 0机构: IRCCS, Ist Scientif Romagnolo Studio & Cura Tumori IRST, I-47014 Meldola, Italy IRCCS, Ist Scientif Romagnolo Studio & Cura Tumori IRST, I-47014 Meldola, ItalyYen, Timothy J.论文数: 0 引用数: 0 h-index: 0机构: Fox Chase Canc Ctr, Canc Biol Program, 7701 Burholme Ave, Philadelphia, PA 19111 USA IRCCS, Ist Scientif Romagnolo Studio & Cura Tumori IRST, I-47014 Meldola, ItalyMartinelli, Giovanni论文数: 0 引用数: 0 h-index: 0机构: IRCCS, Ist Scientif Romagnolo Studio & Cura Tumori IRST, I-47014 Meldola, Italy IRCCS, Ist Scientif Romagnolo Studio & Cura Tumori IRST, I-47014 Meldola, Italy
- [9] Wee1 is required to sustain ATR/Chk1 signaling upon replicative stressONCOTARGET, 2015, 6 (15) : 13072 - 13087Saini, Priyanka论文数: 0 引用数: 0 h-index: 0机构: Univ Gottingen, Inst Mol Oncol, Gottingen Ctr Mol Biosci GZMB, Fac Med, D-37073 Gottingen, Germany Univ Gottingen, Inst Mol Oncol, Gottingen Ctr Mol Biosci GZMB, Fac Med, D-37073 Gottingen, GermanyLi, Yizhu论文数: 0 引用数: 0 h-index: 0机构: Univ Gottingen, Inst Mol Oncol, Gottingen Ctr Mol Biosci GZMB, Fac Med, D-37073 Gottingen, Germany Univ Gottingen, Inst Mol Oncol, Gottingen Ctr Mol Biosci GZMB, Fac Med, D-37073 Gottingen, GermanyDobbelstein, Matthias论文数: 0 引用数: 0 h-index: 0机构: Univ Gottingen, Inst Mol Oncol, Gottingen Ctr Mol Biosci GZMB, Fac Med, D-37073 Gottingen, Germany Univ Gottingen, Inst Mol Oncol, Gottingen Ctr Mol Biosci GZMB, Fac Med, D-37073 Gottingen, Germany
- [10] Inhibition of Chk1 and Wee1 as a new therapeutic approach in Mantle Cell LymphomaCANCER RESEARCH, 2014, 74 (19)Carrassa, Laura论文数: 0 引用数: 0 h-index: 0机构: IRCCS Ist Ric Farmacol Mario Negri, Dept Oncol, Milan, Italy IRCCS Ist Ric Farmacol Mario Negri, Dept Oncol, Milan, ItalyChila, Rosaria论文数: 0 引用数: 0 h-index: 0机构: IRCCS Ist Ric Farmacol Mario Negri, Dept Oncol, Milan, Italy IRCCS Ist Ric Farmacol Mario Negri, Dept Oncol, Milan, ItalyBasana, Alessandra论文数: 0 引用数: 0 h-index: 0机构: IRCCS Ist Ric Farmacol Mario Negri, Dept Oncol, Milan, Italy IRCCS Ist Ric Farmacol Mario Negri, Dept Oncol, Milan, ItalyRicci, Francesca论文数: 0 引用数: 0 h-index: 0机构: IRCCS Ist Ric Farmacol Mario Negri, Dept Oncol, Milan, Italy IRCCS Ist Ric Farmacol Mario Negri, Dept Oncol, Milan, ItalyGuffanti, Federica论文数: 0 引用数: 0 h-index: 0机构: IRCCS Ist Ric Farmacol Mario Negri, Dept Oncol, Milan, Italy IRCCS Ist Ric Farmacol Mario Negri, Dept Oncol, Milan, ItalyLupi, Monica论文数: 0 引用数: 0 h-index: 0机构: IRCCS Ist Ric Farmacol Mario Negri, Dept Oncol, Milan, Italy IRCCS Ist Ric Farmacol Mario Negri, Dept Oncol, Milan, ItalyRinaldi, Andrea论文数: 0 引用数: 0 h-index: 0机构: IOR Inst Oncol Res, Lymphoma & Genom Res Program, Bellinzona, Switzerland IRCCS Ist Ric Farmacol Mario Negri, Dept Oncol, Milan, ItalyCascione, Luciano论文数: 0 引用数: 0 h-index: 0机构: IOR Inst Oncol Res, Lymphoma & Genom Res Program, Bellinzona, Switzerland IRCCS Ist Ric Farmacol Mario Negri, Dept Oncol, Milan, ItalyBertoni, Francesco论文数: 0 引用数: 0 h-index: 0机构: IOR Inst Oncol Res, Lymphoma & Genom Res Program, Bellinzona, Switzerland IOSI Oncol Inst Southern Switzerland, Lymphoma Unit, Bellinzona, Switzerland IRCCS Ist Ric Farmacol Mario Negri, Dept Oncol, Milan, ItalyBroggini, Massimo论文数: 0 引用数: 0 h-index: 0机构: IRCCS Ist Ric Farmacol Mario Negri, Dept Oncol, Milan, Italy IRCCS Ist Ric Farmacol Mario Negri, Dept Oncol, Milan, ItalyDamia, Giovanna论文数: 0 引用数: 0 h-index: 0机构: IRCCS Ist Ric Farmacol Mario Negri, Dept Oncol, Milan, Italy IRCCS Ist Ric Farmacol Mario Negri, Dept Oncol, Milan, Italy