CX3C chemokine mimicry by respiratory syncytial virus G glycoprotein

被引：0

作者：

Ralph A. Tripp

Les P. Jones

Lia M. Haynes

HaoQiang Zheng

Philip M. Murphy

Larry J. Anderson

机构：

[1] National Centers for Infectious Diseases,Division of Viral and Rickettsial Diseases

[2] Respiratory and Enteric Virus Branch,undefined

[3] Mailstop G-09,undefined

[4] Laboratory of Host Defenses,undefined

[5] National Institute of Allergy and Infectious Diseases,undefined

[6] National Institutes of Health,undefined

[7] Building 10,undefined

[8] room 11N113,undefined

来源：

Nature Immunology | 2001年 / 2卷

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D O I：

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摘要：

Chemokines are chemoattractant proteins that are divided into subfamilies based upon cysteine signature motifs termed C, CC, CXC and CX3C. Chemokines have roles in immunity and inflammation that affect cell trafficking and activation of T cells as well as cells of the innate immune system. We report here CX3C chemokine mimicry for the G glycoprotein of respiratory syncytial virus (RSV) and show binding to CX3CR1—the specific receptor for the CX3C chemokine fractalkine—and induction of leukocyte chemotaxis. We also show that CX3CR1 facilitates RSV infection of cells. Thus, G glycoprotein interaction with CX3CR1 probably plays a key role in the biology of RSV infection.

引用

页码：732 / 738

页数：6

共 110 条

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