Enantioseparation of Flobufen with Cyclodextrins Studied by Capillary Electrophoresis and NMR

被引：0
|
作者：
Alexandrine Lambert
Jean-Michel Ballon
Alain Nicolas
机构：
[1] Laboratoire de Chimie Analytique,
[2] Faculté de Pharmacie,undefined
[3] Laboratories Virbac,undefined
来源：
Pharmaceutical Research | 2001年 / 18卷
关键词：
capillary electrophoresis; central composite design; cyclodextrins; enantiomeric separation; flobufen; NMR;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. The aim of this study was to obtain the resolution of flobufen enantiomers, an antiinflammatory active substance, by capillary electrophoresis with cyclodextrins. The mechanism of com- plexation and determination of the stoichiometry of the complexes were studied by NMR and the analytical method was developed and validated.
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页码：886 / 893
页数：7
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