Immunotherapy of brain metastases: breaking a “dogma”

被引：0
作者：
Anna Maria Di Giacomo
Monica Valente
Alfonso Cerase
Maria Fortunata Lofiego
Francesca Piazzini
Luana Calabrò
Elisabetta Gambale
Alessia Covre
Michele Maio
机构：
[1] Center for Immuno-Oncology,Department of Oncology
[2] Medical Oncology and Immunotherapy,Unit of Neuroradiology
[3] University Hospital of Siena,undefined
[4] University Hospital,undefined
来源：
Journal of Experimental & Clinical Cancer Research | / 38卷
关键词：
Brain metastases; Immune checkpoint(s); Cancer immunotherapy; Lung cancer; Magnetic resonance imaging; Melanoma; Neuroradiology; Tumor microenvironment;
D O I：
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中图分类号：
学科分类号：
摘要：
Until very few years ago, the oncology community dogmatically excluded any clinical potential for immunotherapy in controlling brain metastases. Therefore, despite the significant therapeutic efficacy of monoclonal antibodies to immune check-point(s) across a wide range of tumor types, patients with brain disease were invariably excluded from clinical trials with these agents. Recent insights on the immune landscape of the central nervous system, as well as of the brain tumor microenvironment, are shedding light on the immune-biology of brain metastases.
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