Use of Raman spectroscopy as a tool for in situ monitoring of microwave-promoted reactions

被引：0
作者：
Nicholas E Leadbeater
Jason R Schmink
机构：
[1] University of Connecticut,Department of Chemistry
来源：
Nature Protocols | 2008年 / 3卷
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摘要：
The progress of microwave-promoted reactions can be monitored by interfacing a Raman spectrometer with a scientific microwave unit. The apparatus is assembled from commercially available components. It is used in this protocol to follow the base-catalyzed reaction of salicylaldehyde with ethylacetoacetate to yield 3-acetylcoumarin. It is possible to watch the reaction spectroscopically in real time, determine when it reaches completion and thus use it as a tool for rapid reaction optimization.
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页数：6
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