Dynamic DNA methylation programs persistent adverse effects of early-life stress

被引：0
|
作者：
Chris Murgatroyd
Alexandre V Patchev
Yonghe Wu
Vincenzo Micale
Yvonne Bockmühl
Dieter Fischer
Florian Holsboer
Carsten T Wotjak
Osborne F X Almeida
Dietmar Spengler
机构：
[1] Max Planck Institute of Psychiatry,
来源：
Nature Neuroscience | 2009年 / 12卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Severe stress in early childhood can increase an individual's vulnerability to depression later in life. This study found that early-life stress in mice resulted in persistent elevation of the stress hormone arginine vasopressin (AVP), which was caused by persistent hypomethylation of CpG islands in the Avp promoter in the hypothalamus.
引用
收藏
页码：1559 / 1566
页数：7
相关论文
共 50 条
  • [41] Epigenomic profiling of men exposed to early-life stress reveals DNA methylation differences in association with current mental state
    Khulan, B.
    Manning, J. R.
    Dunbar, D. R.
    Seckl, J. R.
    Raikkonen, K.
    Eriksson, J. G.
    Drake, A. J.
    TRANSLATIONAL PSYCHIATRY, 2014, 4 : e448 - e448
  • [42] Epigenomic profiling of men exposed to early-life stress reveals DNA methylation differences in association with current mental state
    B Khulan
    J R Manning
    D R Dunbar
    J R Seckl
    K Raikkonen
    J G Eriksson
    A J Drake
    Translational Psychiatry, 2014, 4 : e448 - e448
  • [43] Programming effects of early-life exposure to heat stress in cattle
    Laporta, Jimena
    JOURNAL OF ANIMAL SCIENCE, 2024, 102 : 18 - 19
  • [44] Programming effects of early-life exposure to heat stress in cattle
    Laporta, Jimena
    JOURNAL OF ANIMAL SCIENCE, 2024, 102
  • [45] Chronic effects on brain development induced by early-life stress
    Takatsuru, Yusuke
    Miyagawa, Kazuya
    FRONTIERS IN NEUROSCIENCE, 2023, 17
  • [46] Effects of early-life stress on fear memory in the developing rat
    Richardson, Rick
    Cowan, Caitlin S. M.
    Callaghan, Bridget L.
    Kan, Janice M.
    CURRENT OPINION IN BEHAVIORAL SCIENCES, 2016, 7 : 15 - 20
  • [47] Effects of Acute and Early-Life Stress on Reward Learning Behavior
    Baranger, David
    Corral-Frias, Nadia
    Winstone, Jonathan
    Barch, Deanna
    Bogdan, Ryan
    BIOLOGICAL PSYCHIATRY, 2017, 81 (10) : S354 - S355
  • [48] Early-life DNA methylation profiles are indicative of age-related transcriptome changes
    Niran Hadad
    Dustin R. Masser
    Laura Blanco-Berdugo
    David R. Stanford
    Willard M. Freeman
    Epigenetics & Chromatin, 12
  • [49] Biological embedding of early-life exposures and disease risk in humans: a role for DNA methylation
    Demetriou, Christiana A.
    van Veldhoven, Karin
    Relton, Caroline
    Stringhini, Silvia
    Kyriacou, Kyriacos
    Vineis, Paolo
    EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2015, 45 (03) : 303 - 332
  • [50] DNA methylation is linked with the cortisol response to stress in early life
    Kertes, Darlene A.
    Leri, John
    Kamin, Hayley
    Bhatt, Samarth
    Kelly, Maria N.
    PSYCHONEUROENDOCRINOLOGY, 2020, 119 : S25 - S25
12345