Dynamic DNA methylation programs persistent adverse effects of early-life stress

被引：0
|
作者：
Chris Murgatroyd
Alexandre V Patchev
Yonghe Wu
Vincenzo Micale
Yvonne Bockmühl
Dieter Fischer
Florian Holsboer
Carsten T Wotjak
Osborne F X Almeida
Dietmar Spengler
机构：
[1] Max Planck Institute of Psychiatry,
来源：
Nature Neuroscience | 2009年 / 12卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Severe stress in early childhood can increase an individual's vulnerability to depression later in life. This study found that early-life stress in mice resulted in persistent elevation of the stress hormone arginine vasopressin (AVP), which was caused by persistent hypomethylation of CpG islands in the Avp promoter in the hypothalamus.
引用
收藏
页码：1559 / 1566
页数：7
相关论文
共 50 条
  • [21] Select Early-Life Environmental Exposures and DNA Methylation in the Placenta
    Mortillo, Michael
    Marsit, Carmen J.
    CURRENT ENVIRONMENTAL HEALTH REPORTS, 2023, 10 (01) : 22 - 34
  • [22] DNA methylation, the early-life social environment and behavioral disorders
    Szyf, Moshe
    JOURNAL OF NEURODEVELOPMENTAL DISORDERS, 2011, 3 (03) : 238 - 249
  • [23] Early-life stress has persistent effects on amygdala function and development in mice and humans
    Cohen, Matthew Malter
    Jing, Deqiang
    Yang, Rui R.
    Tottenham, Nim
    Lee, Francis S.
    Casey, B. J.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (45) : 18274 - 18278
  • [24] The effects of early-life and intergenerational stress on the brain
    LaDage, Lara D.
    McCormick, Gail L.
    Robbins, Travis R.
    Longwell, Anna S.
    Langkilde, Tracy
    PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2023, 290 (2011)
  • [25] Effects of early-life zinc deficiency on learning and memory in offspring and the changes in DNA methylation patterns
    Jiang, Yu-Gang
    Wang, Yong-hui
    Zhang, Han
    Wang, Zi-Yu
    Liu, Yan-Qiang
    NUTRITIONAL NEUROSCIENCE, 2022, 25 (05) : 1001 - 1010
  • [26] Early-life stress and life
    Takatsuru, Yusuke
    AGING-US, 2018, 10 (10): : 2535 - 2536
  • [27] The early-life exposome modulates the effect of polymorphic inversions on DNA methylation
    Natàlia Carreras-Gallo
    Alejandro Cáceres
    Laura Balagué-Dobón
    Carlos Ruiz-Arenas
    Sandra Andrusaityte
    Ángel Carracedo
    Maribel Casas
    Leda Chatzi
    Regina Grazuleviciene
    Kristine Bjerve Gutzkow
    Johanna Lepeule
    Léa Maitre
    Mark Nieuwenhuijsen
    Remy Slama
    Nikos Stratakis
    Cathrine Thomsen
    Jose Urquiza
    John Wright
    Tiffany Yang
    Geòrgia Escaramís
    Mariona Bustamante
    Martine Vrijheid
    Luis A. Pérez-Jurado
    Juan R. González
    Communications Biology, 5
  • [28] The early-life exposome modulates the effect of polymorphic inversions on DNA methylation
    Carreras-Gallo, Natalia
    Caceres, Alejandro
    Balague-Dobon, Laura
    Ruiz-Arenas, Carlos
    Andrusaityte, Sandra
    Carracedo, Angel
    Casas, Maribel
    Chatzi, Leda
    Grazuleviciene, Regina
    Gutzkow, Kristine Bjerve
    Lepeule, Johanna
    Maitre, Lea
    Nieuwenhuijsen, Mark
    Slama, Remy
    Stratakis, Nikos
    Thomsen, Cathrine
    Urquiza, Jose
    Wright, John
    Yang, Tiffany
    Escaramis, Georgia
    Bustamante, Mariona
    Vrijheid, Martine
    Perez-Jurado, Luis A.
    Gonzalez, Juan R.
    COMMUNICATIONS BIOLOGY, 2022, 5 (01)
  • [29] The effect of early-life nutrition on DNA repair and DNA methylation in the brain of newborn piglets
    Langie, S. A. S.
    Tomaszewski, B.
    Kowalczyk, P.
    Godschalk, R. W. L.
    Tudek, B.
    van Schooten, F. J.
    Zabielski, R.
    Mathers, J. C.
    PROCEEDINGS OF THE NUTRITION SOCIETY, 2010, 69 (OCE6) : E471 - E471
  • [30] Early-Life Exposure to the SSRI Paroxetine Disrupts DNA Methylation in the Early Postnatal Hippocampus
    Clinton, Sarah
    Glover, Matthew
    Jackson, Nateka
    McCoy, Chelsea
    NEUROPSYCHOPHARMACOLOGY, 2015, 40 : S127 - S128
12345