Pharmacokinetics and Leukocyte Responses of Recombinant Human Interleukin-10

被引:0
|
作者
Elaine Radwanski
Abhijit Chakraborty
Scott Van Wart
Richard D. Huhn
David L. Cutler
Melton B. Affrime
William J. Jusko
机构
[1] Schering-Plough Research Institute,Department of Pharmaceutics, School of Pharmacy
[2] University of Medicine and Dentistry of New Jersey,undefined
[3] Robert Wood Johnson Medical School,undefined
[4] State University of New York at Buffalo,undefined
来源
Pharmaceutical Research | 1998年 / 15卷
关键词
IL-10; cytokines; protein; immunosuppression; pharmacokinetics;
D O I
暂无
中图分类号
学科分类号
摘要
Purpose. To study the pharmacokinetics and ex vivo leukocyte responses of recombinant human IL-10 (rHuIL-10) following single SC and IV dosing.
引用
收藏
页码:1895 / 1901
页数:6
相关论文
共 50 条
  • [1] Pharmacokinetics and leukocyte responses of recombinant human interleukin-10
    Radwanski, E
    Chakraborty, A
    Van Wart, S
    Huhn, RD
    Cutler, DL
    Affrime, MB
    Jusko, WJ
    PHARMACEUTICAL RESEARCH, 1998, 15 (12) : 1895 - 1901
  • [2] Pharmacokinetics and immunomodulatory properties of intravenously administered recombinant human interleukin-10 in healthy volunteers
    Huhn, RD
    Radwanski, E
    OConnell, SM
    Sturgill, MG
    Clarke, L
    Cody, RP
    Affrime, MB
    Cutler, DL
    BLOOD, 1996, 87 (02) : 699 - 705
  • [3] Preclinical safety evaluation of recombinant human interleukin-10
    Rosenblum, LY
    Johnson, RC
    Schmahai, TJ
    REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2002, 35 (01) : 56 - 71
  • [4] Modulation of Human Immune Responses by Bovine Interleukin-10
    den Hartog, Gerco
    Savelkoul, Huub F. J.
    Schoemaker, Ruud
    Tijhaar, Edwin
    Westphal, Adrie H.
    de Ruiter, Talitha
    van de Weg-Schrijver, Elise
    van Neerven, R. J. Joost
    PLOS ONE, 2011, 6 (03):
  • [5] Recombinant human interleukin-10 in patients with chronic myelomonocytic leukemia
    Sophie Pöchlauer
    Eva Jäger
    Ulrich Jäger
    Klaus Geissler
    Annals of Hematology, 2014, 93 : 1775 - 1776
  • [6] Recombinant human interleukin-10 in patients with chronic myelomonocytic leukemia
    Poechlauer, S.
    Jaeger, E.
    Jaeger, U.
    Geissler, K.
    ONKOLOGIE, 2013, 36 : 241 - 241
  • [7] Recombinant human interleukin-10 in patients with chronic myelomonocytic leukemia
    Poechlauer, Sophie
    Jaeger, Eva
    Jaeger, Ulrich
    Geissler, Klaus
    ANNALS OF HEMATOLOGY, 2014, 93 (10) : 1775 - 1776
  • [8] CHARACTERIZATION OF RECOMBINANT EXTRACELLULAR DOMAIN OF HUMAN INTERLEUKIN-10 RECEPTOR
    TAN, JC
    BRAUN, S
    RONG, H
    DIGIACOMO, R
    DOLPHIN, E
    BALDWIN, S
    NARULA, SK
    ZAVODNY, PJ
    CHOU, CC
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (21) : 12906 - 12911
  • [9] Pharmacodynamics of subcutaneous recombinant human interleukin-10 in healthy volunteers
    Huhn, RD
    Radwanski, E
    Gallo, J
    Affrime, MB
    Sabo, R
    Gonyo, G
    Monge, A
    Cutler, DL
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 1997, 62 (02) : 171 - 180
  • [10] In vivo effects of recombinant human interleukin-10 lymphocyte phenotypes and leukocyte activation markers inflammatory bowel disease
    Dejaco, C
    Reinisch, W
    Lichtenberger, C
    Waldhoer, T
    Kuhn, I
    Tilg, H
    Gasche, C
    JOURNAL OF INVESTIGATIVE MEDICINE, 2000, 48 (06) : 449 - 456