Inhibition of Contractions of Nerve Processes in Calcium-Free Medium

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作者
O. S. Sotnikov
N. Yu. Vasiagina
G. I. Rybakova
S. V. Chepur
机构
[1] Russian Academy of Sciences,Laboratory of Functional Morphology and Physiology of Neuron, I. P. Pavlov Institute of Physiology
关键词
isolated neuron; neurite contraction; calcium channel blocker; nimodipine; nitrendipine;
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摘要
The possibility of blocking contractile activity of damaged neurites was studied on viable isolated neurons from Lymnaea stagnalis mollusks. Retraction was blocked in more than 80% cells plunged in Ringer’s solution free from Ca2+ or containing 20 mM CoCl2. Nimodipine and nitrendipine significantly inhibited neurite contractions. Inhibition of neurite contractile activity can be useful for reducing diastasis after nerve crossing.
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页码:265 / 268
页数:3
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