Challenges and advancements in bioprocess intensification of fungal secondary metabolite: kojic acid

被引：0
作者：
Sumit Sharma
Shikha Singh
Saurabh Jyoti Sarma
机构：
[1] Bennett University,Department of Biotechnology, School of Engineering and Applied Sciences
来源：
World Journal of Microbiology and Biotechnology | 2023年 / 39卷
关键词：
Kojic acid; Metabolic networks; Genetic regulations; Process improvements; Industrial security; Derivatization;
D O I：
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学科分类号：
摘要：
Kojic acid is a fungal secondary metabolite commonly known as a tyrosinase inhibitor, that acts as a skin-whitening agent. Its applications are widely distributed in the area of cosmetics, medicine, food, and chemical synthesis. Renewable resources are the alternative feedstocks that can fulfill the demand for free sugars which are fermented for the production of kojic acid. This review highlights the current progress and importance of bioprocessing of kojic acid from various types of competitive and non-competitive renewable feedstocks. The bioprocessing advancements, secondary metabolic pathway networks, gene clusters and regulations, strain improvement, and process design have also been discussed. The importance of nitrogen sources, amino acids, ions, agitation, and pH has been summarized. Two fungal species Aspergillus flavus and Aspergillus oryzae are found to be extensively studied for kojic acid production due to their versatile substrate utilization and high titer ability. The potential of A. flavus to be a competitive industrial strain for large-scale production of kojic acid has been studied.
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[31]  
Chang TS(2015)Optimisation and characterisation of lipase-catalysed synthesis of a kojic monooleate ester in a solvent-free system by response surface methodology PLoS ONE 12 1087-9
[32]  
Chang PK(2013)Fungus-specific sirtuin HstD coordinates secondary metabolism and development through control of LaeA Eukaryot Cell 20 461-2754
[33]  
Ehrlich KC(2008)Enzymatic synthesis and characterization of palm-based kojic acid ester J Oil Palm Res 8 713-303
[34]  
Chang PK(2007)Aspergillus flavus: the major producer of aflatoxin Mol Plant Pathol 133 235-1133
[35]  
Hua SST(2022)New role of a histone chaperone, HirA: involvement in kojic acid production associated with culture conditions in aspergillus oryzae J Biosci Bioeng 5 256-43
[36]  
Sarreal SBL(2016)Use of coconut coir fibers as an inert solid support for kojic acid production under solid state fermentation Int J Curr Microbiol Appl Sci 323 124566-464
[37]  
Li RW(2021)Recent developments on solid-state fermentation for production of microbial secondary metabolites: Challenges and solutions Bioresour Technol 39 903-30
[38]  
Chaudhary J(1992)Cultivation characteristics of immobilized aspergillus oryzae for kojic acid production Biotechnol Bioeng 118 133-24
[39]  
Pathak AN(2018)Release of simple sugars from lignocellulosic biomass of Agave salmiana leaves subject to sequential pretreatment and enzymatic saccharification Biomass Bioenergy 67 573-982
[40]  
Lakhawat S(2013)Enzymatic synthesis of kojic acid esters and their potential industrial applications Chem Pap 55 14737-79
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