Challenges and advancements in bioprocess intensification of fungal secondary metabolite: kojic acid

被引：0
作者：
Sumit Sharma
Shikha Singh
Saurabh Jyoti Sarma
机构：
[1] Bennett University,Department of Biotechnology, School of Engineering and Applied Sciences
来源：
World Journal of Microbiology and Biotechnology | 2023年 / 39卷
关键词：
Kojic acid; Metabolic networks; Genetic regulations; Process improvements; Industrial security; Derivatization;
D O I：
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学科分类号：
摘要：
Kojic acid is a fungal secondary metabolite commonly known as a tyrosinase inhibitor, that acts as a skin-whitening agent. Its applications are widely distributed in the area of cosmetics, medicine, food, and chemical synthesis. Renewable resources are the alternative feedstocks that can fulfill the demand for free sugars which are fermented for the production of kojic acid. This review highlights the current progress and importance of bioprocessing of kojic acid from various types of competitive and non-competitive renewable feedstocks. The bioprocessing advancements, secondary metabolic pathway networks, gene clusters and regulations, strain improvement, and process design have also been discussed. The importance of nitrogen sources, amino acids, ions, agitation, and pH has been summarized. Two fungal species Aspergillus flavus and Aspergillus oryzae are found to be extensively studied for kojic acid production due to their versatile substrate utilization and high titer ability. The potential of A. flavus to be a competitive industrial strain for large-scale production of kojic acid has been studied.
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[11]  
Ariff AB(2011)A fungal enzyme with the ability of aflatoxin B1 conversion: purification and ESI-MS/MS identification Microbiol Res 10 2440-3196
[12]  
Salleh MS(2009)An updated review of tyrosinase inhibitors Int J Mol Sci 138 189-605
[13]  
Ghani B(2010)What does genetic diversity of aspergillus flavus tell us about Aspergillus oryzae? Int J Food Microbiol 7 3887-9
[14]  
Ariff AB(2015)Suppression of aflatoxin biosynthesis in aspergillus flavus by 2-phenylethanol is associated with stimulated growth and decreased degradation of branched-chain amino acids Toxins (Basel) 4 3165-6002
[15]  
Mohamad R(2014)Production technology and applications of kojic acid Annu Res Rev Biol 82 601-135
[16]  
Herng LS(2002)Optimisation of kojic acid monolaurate synthesis with lipase PS from Pseudomonas cepacia J Sci Food Agric 8 885-473
[17]  
Ashari SE(2022)A novel major facilitator superfamily transporter gene Aokap4 near the kojic acid gene cluster is involved in growth and kojic acid production in aspergillus oryzae J Fungi 38 1-10
[18]  
Mohamad R(2022)Disruption of Aokap6 near the kojic acid gene cluster affects the growth and kojic acid production in aspergillus oryzae World J Microbiol Biotechnol 46 5995-761
[19]  
Ariff A(2019)Consistent production of kojic acid from Aspergillus sojae SSC-3 isolated from rice husk Mol Biol Rep 150 84-365
[20]  
Bajpai P(2010)Kojic acid production from glycerol: optimization using central composite rotatable design J Biotechnol 78 115-1882
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