Fetal and perinatal programming of renal function

被引：0
作者：
Dötsch J. [1 ]
机构：
[1] Klinik und Poliklinik für Kinder- und Jugendmedizin, Uniklinik Köln, 50937 Köln
来源：
Gynäkologische Endokrinologie | 2014年 / 12卷 / 2期
关键词：
Birth weight; Glomerular filtration rate; Intrauterine environment; Intrauterine growth retardation; Pregnancy;
D O I：
10.1007/s10304-013-0593-z
中图分类号：
学科分类号：
摘要：
Impact. Low birth weight is associated with reduced renal function which is sometimes already present in childhood. Among the diseases that are encountered more frequently or are more severe are glomerular diseases, hypertension, and chronic kidney disease. Causes. A potential cause of this phenomenon is fetal programming which is defined as a permanent alteration of biological function by a temporary intrauterine event. However, low birth weight is not the only factor influencing renal function via fetal programming. Other factors include maternal diabetes, maternal smoking, high salt intake, and the administration of glucocorticoids during pregnancy. Mechanisms. Possible mechanisms that may be involved are impaired nephrogenesis, which is represented by a diminished number of nephrons and other renal and extrarenal mechanisms. Human and animal data suggest that the consequences of fetal programming are influenced by the postnatal environment to a large extent. One of those postnatal modifiers appears to be nutrition in infancy and early childhood. © 2014 Springer-Verlag.
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页码：87 / 92
页数：5
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