Hypoxic Hepatocellular Carcinoma Cells Acquire Arsenic Trioxide Resistance by Upregulating HIF-1α Expression

被引:0
|
作者
Yaoting Chen
Huiqing Li
Dong Chen
Xiongying Jiang
Weidong Wang
Dan Li
Hong Shan
机构
[1] Sun Yat-sen University,Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation and Department of Interventional Radiology, Sun Yat
[2] Sun Yat-sen University,sen Memorial Hospital
[3] Sun Yat-sen University,Health Center, Sun Yat
[4] Sun Yat-sen University,sen Memorial Hospital
[5] Sun Yat-sen University,Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital
来源
关键词
Hepatocellular carcinoma; Arsenic trioxide; Drug resistance; HIF-1α; Targeted therapy;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:3806 / 3816
页数:10
相关论文
共 50 条
  • [41] Cytotoxic effects of Phenformin on ovarian cancer cells: expression of HIF-1α and PDK1 in the hypoxic microenvironment
    Gunaydin, Burcu
    Yigitturk, Gurkan
    Elbe, Hulya
    ROMANIAN JOURNAL OF MORPHOLOGY AND EMBRYOLOGY, 2023, 64 (03): : 355 - 361
  • [42] Inhibition of protein synthesis by imexon reduces HIF-1α expression in normoxic and hypoxic pancreatic cancer cells
    Samulitis, Betty K.
    Landowski, Terry H.
    Dorr, Robert T.
    INVESTIGATIONAL NEW DRUGS, 2009, 27 (01) : 89 - 98
  • [43] Inhibition of protein synthesis by imexon reduces HIF-1α expression in normoxic and hypoxic pancreatic cancer cells
    Betty K. Samulitis
    Terry H. Landowski
    Robert T. Dorr
    Investigational New Drugs, 2009, 27 : 89 - 98
  • [44] Rac promotes angiogenesis in hepatocellular carcinoma by stablizing HIF-1α protein
    Lee, Terence
    Yuen, Anthony Po Wing
    Poon, Ronnie Tung Ping
    CANCER RESEARCH, 2006, 66 (08)
  • [45] Arsenic trioxide potentiates sensitivity of multiple myeloma cells to lenalidomide by upregulating cereblon expression levels
    Jian, Yuan
    Ga, Wen
    Geng, Chuanying
    Zhou, Huixing
    Leng, Yun
    Li, Yanchen
    Chen, Wenming
    ONCOLOGY LETTERS, 2017, 14 (03) : 3243 - 3248
  • [46] 3,3′-diindolylmethane reduces levels of HIF-1α and HIF-1 activity in hypoxic cultured human cancer cells
    Riby, Jacques E.
    Firestone, Gary L.
    Bieldanes, Leonard F.
    BIOCHEMICAL PHARMACOLOGY, 2008, 75 (09) : 1858 - 1867
  • [47] Influence of preoperative transcatheter arterial chemoembolization on gene expression in the HIF-1α pathway in patients with hepatocellular carcinoma
    Xu, Weiguang
    Kwon, Jung-Hee
    Moon, Young Ho
    Kim, Young Bae
    Yu, Yun Suk
    Lee, Namgyu
    Choi, Kwan Yong
    Kim, Yun Soo
    Park, Yong Keun
    Kim, Bong Wan
    Wang, Hee Jung
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2014, 140 (09) : 1507 - 1515
  • [48] Rapamycin-resistant HIF-1α expression in hepatocellular carcinoma (HCC) cells and high sensitivity of endothelial cells within HCC tissues to rapamycin
    Tanaka, Hiroki
    Yamamoto, Masahiro
    Miyakoshi, Masaaki
    Ogawa, Katsuhiro
    CANCER RESEARCH, 2013, 73 (08)
  • [49] Influence of preoperative transcatheter arterial chemoembolization on gene expression in the HIF-1α pathway in patients with hepatocellular carcinoma
    Weiguang Xu
    Jung-Hee Kwon
    Young Ho Moon
    Young Bae Kim
    Yun Suk Yu
    Namgyu Lee
    Kwan Yong Choi
    Yun Soo Kim
    Yong Keun Park
    Bong Wan Kim
    Hee Jung Wang
    Journal of Cancer Research and Clinical Oncology, 2014, 140 : 1507 - 1515
  • [50] HIF-1α ODD polypeptides increased the expression of HIF1 and VEGF in hypoxic rat cortical neuron
    Xuemin Liu
    Juan Du
    Qi Xi
    Neurological Sciences, 2011, 32 : 1029 - 1033