Clinical significance of estrogen receptor β in breast cancer

被引：2
作者：
Iwase H. [1 ]
Omoto Y. [1 ]
Toyama T. [1 ]
Hara Y. [1 ]
Iwata H. [2 ]
Kobayashi S. [3 ]
机构：
[1] Department of Surgery II, Breast and Endocrine Surgery, Nagoya City University, Medical School, Kawasumi 1, Mizuho-ku
[2] Department of Breast Surgery, Aichi Cancer Center
[3] Department of Surgery, Higashi Municipal Hospital of Nagoya
来源：
Breast Cancer | 1999年 / 6卷 / 4期
关键词：
Breast cancer; Estrogen receptor β; Immunohistochemistry; MRNA;
D O I：
10.1007/BF02966448
中图分类号：
学科分类号：
摘要：
To estimate the clinical significance of estrogen receptor (ER) β in breast cancer we reviewed some reports and compared them with our preliminary results. The structure of ERβ is similar to that of ERar. The DNA binding domain of ERβ is 96% conserved compared with ERα, and the ligand binding domain shows 58% conserved residues, suggesting that both receptors can bind estrogen responsive elements on target genes and that they may also bind similar ligand. The target tissues of ERβ such as testis, prostate, lung, brain, thymus, and ovary, are different from those of ERα, ovary, uterus, endometrium, and breast. Although the function of ERβ in breast cancer progression is not well understood, 30-50% of breast cancers may express ERβ mRNA signals. Additionally, ERβ may be a useful prognostic factor in patients with breast cancer, because tumors that co-expressed ERα and ERβ might be node positive and tend to be of higher grade. Further characterization of the function of ERβ and its isoforms in breast cancer is warranted.
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收藏
页码：325 / 330
页数：5
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