Clinical and epidemiological aspects of SARS-CoV-2 infection among pregnant and postpartum women in Mozambique: a prospective cohort study; [Aspectos clínicos e epidemiológicos da infeção pelo SARS-CoV-2 em mulheres gestantes e puérperas de Moçambique: um estudo de coorte prospectivo]; [Aspectos clínicos y epidemiológicos de la infección por SARS-CoV-2 en mujeres embarazadas y puérperas en Mozambique: un estudio de cohorte prospectivo]

被引：0

作者：

Charles C.M. ^{[1
,2
]}

Osman N.B. ^{[3
,4
]}

Arijama D. ^{[3
]}

Matingane B. ^{[3
,4
]}

Sitoé T. ^{[3
]}

Kenga D. ^{[5
]}

Lorenzoni C. ^{[6
,7
]}

Luís E. ^{[3
,4
]}

Pacagnella R.C. ^{[2
]}

Sacarlal J. ^{[5
]}

Passanduca A.

Manjate A.

Munezero A.

Uassiquete C.

Majunta F.

Nobrega G.M.

Cambaza I.

Carlos J.

Cecatti J.G.

Costa M.L.

Souza R.T.

Taúnde S.

Mussá T.

机构：

[1] Provincial Health Administration, DPS Manica, Manica Province, Chimoio

[2] Department of Obstetrics and Gynecology, School of Medicine, University of Campinas, Campinas, São Paulo

[3] Department of Obstetrics and Gynecology, Maputo Central Hospital, Maputo

[4] Department of Obstetrics and Gynecology, Faculty of Medicine, Eduardo Mondlane University, Maputo

[5] Department of Microbiology, Faculty of Medicine, Eduardo Mondlane University, Maputo

[6] Pathology Department, Faculty of Medicine, Eduardo Mondlane University, Maputo

[7] Pathological Anatomy Service, Maputo Central Hospital, Maputo

来源：

Reproductive Health | / 19卷 / 1期

关键词：

COVID-19; Low-income country; Maternal and perinatal morbidity; Mozambique; Risk factors;

D O I：

10.1186/s12978-022-01469-9

中图分类号：

学科分类号：

摘要：

Background: Although there is a significant increase of evidence regarding the prevalence and impact of COVID-19 on maternal and perinatal outcomes, data on the effects of the pandemic on the obstetric population in sub-Saharan African countries are still scarce. Therefore, the study aims were to assess the prevalence and impact of COVID-19 on maternal and neonatal outcomes in the obstetric population at Central Hospital of Maputo (HCM), Mozambique. Methods: Prospective cohort study conducted at teaching and referral maternity, HCM, from 20 October 2020 to 22 July 2021. We collected maternal and perinatal outcomes up to 6 weeks postpartum of eligible women (pregnant and postpartum women—up to the 14th day postpartum) screened for COVID-19 (individual test for symptomatic participants and pool testing for asymptomatic). The primary outcome was maternal death, Severe Acute Respiratory Syndrome (SARS) and Intensive Care Unit (ICU) admission. We estimated the COVID-19 prevalence and the unadjusted RR (95% CI) for maternal and perinatal outcomes. We used the chi-square or Fisher's exact test to compare categorical variables (two-sided p-value < 0.05 for statistical significance). Results: We included 239 participants. The overall prevalence of COVID-19 was 9.2% (22/239) and in the symptomatic group was 32.4% (11/34). About 50% of the participants with COVID-19 were symptomatic. Moreover, the most frequent symptoms were dyspnoea (33.3%), cough (28.6%), anosmia (23.8%), and fever (19%). Not having a partner, being pregnant, and alcohol consumption were vulnerability factors for SARS-CoV-2 infection. The risk of adverse maternal and neonatal outcomes (abortion, foetal death, preterm birth, Apgar, and NICU admission) was not significantly increased with COVID-19. Moreover, we did not observe a significant difference in the primary outcomes (SARS, ICU admission and maternal death) between COVID-19 positive and COVID-19 negative groups. Conclusion: The prevalence of COVID-19 in the obstetric population is higher than in the general population, and fifty percent of pregnant and postpartum women with COVID-19 infection are asymptomatic. Not having a partner and alcohol consumption were factors of greatest vulnerability to SARS-COV-2 infection. Moreover, being pregnant versus postpartum was associated with increased vulnerability to COVID-19. Data suggest that pregnant women with COVID-19 may have a higher frequency of COVID-19 infection, reinforcing the need for universal testing, adequate follow-up for this population, and increasing COVID-19 therapy facilities in Mozambique. Moreover, provide counselling during Antenatal care for COVID-19 preventive measures. However, more prospective and robust studies are needed to assess these findings. © 2022, The Author(s).

引用

共 34 条

[1]

Massinga L.M., Tshangela A., Salyer S.J., Varma J.K., Ouma A.E.O., Nkengasong J.N., COVID-19 in Africa: the spread and response, Nat Med, 26, 7, pp. 999-1003, (2020)

[2]

Umviligihozo G., Mupfumi L., Sonela N., Naicker D., Obuku E.A., Koofhethile C., Et al., Sub-Saharan Africa preparedness and response to the COVID-19 pandemic: a perspective of early career African scientists, Wellcome Open Res, 5, (2020)

[3]

Walker P.G.T., Whittake C., Watson O., Marc B., Ainslie K.E.C., Bhatia S., Et al., The Global Impact of COVID-19 and Strategies for Mitigation and Suppression, (2020)

[4]

Salyer S.J., Maeda J., Sembuche S., Kebede Y., Tshangela A., Moussif M., Ihekweazu C., Mayet N., Abate E., Et al., The first and second waves of the COVID-19 pandemic in Africa: a cross- sectional study, Lancet, 397, pp. 1265-1275, (2021)

[5]

COVID-19—virtual press conference—30 March 2020: Geneve, (2020)

[6]

Ritchie H., Mathieu E., Rodes-Guirao L., Appel C., Giattino C., Ortiz-Ospina E., Et al., Coronavirus Pandemic (COVID-19). Our World in Data, (2021)

[7]

Cepheid Xpert Xpress SARS-CoV-2 has received FDA emergency use authorisation, (2020)

[8]

Chiang C.Y., Sony A.E., Tackling the threat of COVID-19 in Africa: an urgent need for practical planning, Int J Tuberc Lung Dis, (2020)

[9]

Ministério da Saúde, Direcção nacional de Saúde Pública, Centro Operativo de Emergência em Saúde Pública. Painel Epidemiológico SARS-CoV-2—República de Moçambique, (2021)

[10]

Pulse Survey on Continuity of Essential Healt Services during the COVID-19 Pandemic: Interim Report, 27 August 2020. Geneva, (2020)

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