Non-stem cell-derived exosomes: a novel therapeutics for neurotrauma

被引：0
作者：
Xinyu Nie
Tianyang Yuan
Tong Yu
Zhihe Yun
Tao Yu
Qinyi Liu
机构：
[1] The second hospital of Jilin University,Department of Orthopaedic
来源：
Journal of Nanobiotechnology | / 22卷
关键词：
Exosomes; Neurotrauma; Therapeutics; Tissue regeneration; Non-stem cell sources;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Neurotrauma, encompassing traumatic brain injuries (TBI) and spinal cord injuries (SCI) impacts a significant portion of the global population. While spontaneous recovery post-TBI or SCI is possible, recent advancements in cell-based therapies aim to bolster these natural reparative mechanisms. Emerging research indicates that the beneficial outcomes of such therapies might be largely mediated by exosomes secreted from the administered cells. While stem cells have garnered much attention, exosomes derived from non-stem cells, including neurons, Schwann cells, microglia, and vascular endothelial cells, have shown notable therapeutic potential. These exosomes contribute to angiogenesis, neurogenesis, and axon remodeling, and display anti-inflammatory properties, marking them as promising agents for neurorestorative treatments. This review provides an in-depth exploration of the current methodologies, challenges, and future directions regarding the therapeutic role of non-stem cell-derived exosomes in neurotrauma.
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