Genomic characterization of three bacteriophages infecting donkey-derived Escherichia coli

被引:0
作者
Jia-Qi Cui
Wen-Hua Liu
Can Zhang
Ling Zou
Hui-Ying Ren
机构
[1] Qingdao Agricultural University,College of Veterinary Medicine
来源
Virus Genes | 2023年 / 59卷
关键词
Phage; Whole-genome sequencing; Gene annotation;
D O I
暂无
中图分类号
学科分类号
摘要
Bacteriophages are an important source of novel genetic diversity. Sequencing of phage genomes can reveal new proteins with potential uses in phage therapy and help unravel the diversity of biological mechanisms by which phages take over the machinery of the host during infection. To expand the available collection of phage genomes, we have isolated, sequenced, and assembled the genome sequences of three phages that infect three pathogenic Escherichia coli strains: vB_EcoM_DE15, vB_EcoM_DE16, and vB_EcoM_DE17. Morphological characterization and genomic analysis indicated that all three phages were strictly lytic and free from integrases, virulence factors, toxins, and antimicrobial resistance genes. All three phages contained tRNAs, and especially, vB_EcoM_DE17 contained 25 tRNAs. The genomic features of these phages indicate that natural phages are capable of lysing pathogenic E.coli and have great potential in the biocontrol of bacteria.
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页码:752 / 762
页数:10
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