Anti-Hyperuricemic Effect of Iron Oxide Nanoparticles against Monosodium Urate Crystals Induced Gouty Arthritis in BALB/c Mice

被引：0
作者：
Mubin Mustafa Kiyani
Nurain Baig Moghul
Maisra Azhar Butt
Hamza Rehman
Ramsha Masood
Tausif Ahmed Rajput
Syed Ali Imran Bokhari
机构：
[1] Shifa Tameer-e-Millat University,Shifa College of Medical Technology
[2] Shaheed Zulfiqar Ali Bhutto Medical University (SZABMU),Rawal Institute of Health Sciences
[3] Riphah International University,Faculty of Rehabilitation and Allied Health Sciences
[4] International Islamic University,Department of Bioinformatics and Biotechnology
[5] University of Lahore,Department of Rehabilitation Sciences
[6] Shifa Tameer-e-Millat University,Faculty of Pharmaceutical & Allied Health Sciences
来源：
Biological Trace Element Research | 2022年 / 200卷
关键词：
Nanoparticles; Hyperuricemia; Uric acid; Histology;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Iron oxide nanoparticles (FeO-NPs) exhibit exceptional properties which can be utilized in various aspects of biological sciences. In this experiment we investigated the anti-gout effectiveness of FeO-NPs in mice. BALB/c mice were induced gouty arthritis by administering monosodium urate (MSU) crystals. These gout induced mice were treated with three different concentrations of FeO-NPs (5 ppm, 10 ppm and 20 ppm). Precipitation method was utilized for the synthesis of FeO-NPs, these synthesized NPs were of average 54 nm in size and were characterized using XRD, SEM and EDS. FeO-NPs is given orally three weeks by using FeO-NPs solution to substitute drinking water. Blood biochemical parameters including liver function tests (LFTs), renal function tests (RFTs), lipid profile and blood count have been tested. It has been found that uric acid, blood urea and creatinine have decreased significantly after three weeks of FeO-NP administration (P Value < 0.001) thus suppressing hyperuricemia and gouty arthritis. Additionally, the liver enzymes analysis showed a slight increase in AST, ALT and alkaline phosphatase levels (P Value < 0.001). Histopathological research revealed no significant abnormal changes in the liver, muscle and kidney muscles of the test groups. The findings showed that FeO-NPs can be used for the successful treatment of hyperuricemic condition and gouty arthritis in the coming future in place of commercially available medicines.
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页码：1659 / 1666
页数：7
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