Expression of Aβ42, τ-Protein, p16, p53 in Buccal Epithelium: Prospects for Use in the Diagnostics of Alzheimer’s Disease and Rate of Aging

被引：0
作者：
V. A. Zuev
A. S. Dyatlova
N. S. Lin’kova
T. V. Kvetnaya
机构：
[1] St. Petersburg Research Center Institute of Bioregulation and Gerontology,
[2] Peter the Great St. Petersburg Polytechnic University,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2019年 / 166卷
关键词：
buccal epithelium; Alzheimer’s disease; Aβ42 protein; τ-protein; aging;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The expression of Aβ42, and τ-protein, and p16 and p53 proteins was analyzed in the buccal epithelium of elderly and senile patients with Alzheimer’s disease. We revealed enhanced synthesis of Alzheimer’s disease markers Aβ42 (by 15-30 times) and τ-protein (by 5 times) in comparison with the corresponding values in people without neurodegenerative pathology of the same age groups. In addition, increased synthesis of proteins of cell aging and apoptosis p16 (by 6-10 times) and p53 (by 2-3 times) was observed in patients in comparison with age-matched persons without neuropathology. These data suggest that complex analysis of the expression of Aβ42, τ-protein, p16, and p53 in the buccal epithelium is a promising method for in vivo diagnosis of Alzheimer’s disease and assessment of the rate of aging during the development of this pathology.
引用
收藏
页码：676 / 679
页数：3
相关论文
共 91 条
  • [1] Ankarcrona M(2016)Current and future treatment of amyloid diseases J. Intern. Med. 280 177-202
  • [2] Winblad B(2014)A critical analysis of the ‘amyloid cascade hypothesis’ Folia Neuropathol. 52 211-225
  • [3] Monteiro C(2016)Meta-analysis of telomere length in Alzheimer’s disease J. Gerontol. A Biol. Sci. Med. Sci. 71 1069-1073
  • [4] Fearns C(2016)The Australian Imaging Biomarkers and Lifestyle Study Research Group. High content, multi-parameter analyses in buccal cells to identify Alzheimer’s disease Curr. Alzheimer Res. 13 787-799
  • [5] Powers ET(2014)Biomarkers of Alzheimer’s disease risk in peripheral tissues; focus on buccal cells Curr. Alzheimer Res. 11 519-531
  • [6] Johansson J(2017)Quantitative 3D telomeric imaging of buccal cells reveals Alzheimer’s disease-specific signatures J. Alzheimers Dis. 58 139-145
  • [7] Westermark GT(2003)Möbius HJ. Tolerability of memantine in combination with cholinesterase inhibitors in dementia therapy Int. Clin. Psychopharmacol. 18 81-85
  • [8] Presto J(2002)The tau protein of oral epithelium increases in Alzheimer’s disease J. Gerontol. A Biol. Sci. Med. Sci. 57 M64-M70
  • [9] Ericzon BG(2015)PKCε deficits in Alzheimer’s disease brains and skin fibroblasts J. Alzheimers Dis. 43 491-509
  • [10] Kelly JW(1998)The liver in systemic amyloidosis: insights from 123I serum amyloid P component scintigraphy in 484 patients Gut. 42 727-734
12345678910