CYP1A2 and CYP2D6 Gene Polymorphisms in Schizophrenic Patients with Neuroleptic Drug-Induced Side Effects

被引：0
作者：
S. A. Ivanova
M. L. Filipenko
N. M. Vyalova
E. N. Voronina
I. V. Pozhidaev
D. Z. Osmanova
M. V. Ivanov
O. Yu. Fedorenko
A. V. Semke
N. A. Bokhan
机构：
[1] Research Institute of Mental Health,Institute of Chemical Biology and Basic Medicine
[2] Siberian Division of the Russian Academy of Sciences,St. Petersburg V. M. Bekhterev Psychoneurological Research Institute
[3] National Research Tomsk Polytechnical University,undefined
[4] National Research Tomsk State University,undefined
[5] Ministry of Health of the Russian Federation,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2016年 / 160卷
关键词：
schizophrenia; tardive dyskinesia; hyperprolactinemia; gene polymorphism; Cytochromes;
D O I：
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学科分类号：
摘要：
Polymorphic variants of CYP1A2 and CYP2D6 genes of the cytochrome P450 system were studied in patients with schizophrenia with drug-induced motor disorders and hyperprolactinemia against the background of long-term neuroleptic therapy. We revealed an association of polymorphic variant C-163A CYP1A2*1F of CYP1A2 gene with tardive dyskinesia and association of polymorphic variant 1846G>A CY2D6*4 and genotype A/A of CYP2D6 gene (responsible for debrisoquin-4-hydroxylase synthesis) with limbotruncal tardive dyskinesia in patients with schizophrenia receiving neuroleptics for a long time.
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页码：687 / 690
页数：3
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