Negative regulation of cytokine signaling and immune responses by SOCS proteins

被引：0
作者：
Akihiko Yoshimura
Hitomi Nishinakamura
Yumiko Matsumura
Toshikatsu Hanada
机构：
[1] Medical Institute of Bioregulation,Division of Molecular and Cellular Immunology
[2] Kyushu University,undefined
来源：
Arthritis Research & Therapy | / 7卷
关键词：
Synovial Fibroblast; SOCS3 Expression; Epidermal Growth Factor Signaling; Important Negative Regulator; Kinase Inhibitory Region;
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摘要：
Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. Many of these cytokines exert their biological functions through JAKs (Janus tyrosine kinases) and STAT (signal transduction and activators of transcription) transcription factors. CIS (cytokine-inducible SH2 (Src homology 2) protein) and SOCS (suppressor of cytokine signaling) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine-mediated homeostasis, including innate and adaptive immunity. In this review we focus on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in immune regulation and inflammatory diseases including rheumatoid arthritis.
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