Facile synthesis of chiral N-glycosylated amino acids

被引：0

作者：

Lin Fa Wang

Ling Qiang Kong

Li Fan

Da Cheng Yang

机构：

[1] Southwest University,College of Chemistry and Chemical Engineering

来源：

Research on Chemical Intermediates | 2010年 / 36卷

关键词：

-Glycosylated amino acid; Fmoc-protected amino acid; Glucosamine; Chiral;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Five designed chiral glycosylated amino acids have been synthesized for the first time by coupling of 1,3,4,6-tetra-O-acetyl-β-D-glucosamine sulfate (2), previously prepared by direct acetylation of D-glucosamine hydrochloride with acetic anhydride, with chiral Fmoc-protected amino acids and DIC, HOBt, and DIEA under mild conditions. The structures of these new compounds were characterized by IR, 1H NMR, and 13C NMR spectroscopy and ESI MS.

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页码：237 / 243

页数：6

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