Facile synthesis of chiral N-glycosylated amino acids

被引：0
|
作者：
Lin Fa Wang
Ling Qiang Kong
Li Fan
Da Cheng Yang
机构：
[1] Southwest University,College of Chemistry and Chemical Engineering
来源：
Research on Chemical Intermediates | 2010年 / 36卷
关键词：
-Glycosylated amino acid; Fmoc-protected amino acid; Glucosamine; Chiral;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Five designed chiral glycosylated amino acids have been synthesized for the first time by coupling of 1,3,4,6-tetra-O-acetyl-β-D-glucosamine sulfate (2), previously prepared by direct acetylation of D-glucosamine hydrochloride with acetic anhydride, with chiral Fmoc-protected amino acids and DIC, HOBt, and DIEA under mild conditions. The structures of these new compounds were characterized by IR, 1H NMR, and 13C NMR spectroscopy and ESI MS.
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页码：237 / 243
页数：6
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