Blood interactions with plasticized poly(vinyl chloride): relevance of plasticizer selection

被引：0

作者：

H. Q. Yin

X. B. Zhao

J. M. Courtney

C. R. Blass

R. H. West

G. D. O. Lowe

机构：

[1] University of Strathclyde,Bioengineering Unit

[2] Hydro Polymers Ltd,Department of Medicine

[3] CSMA Ltd,undefined

[4] Royal Infirmary,undefined

来源：

Journal of Materials Science: Materials in Medicine | 1999年 / 10卷

关键词：

Adsorption Capacity; Thrombin; Fibrinogen; Phthalate; DEHP;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

An investigation has been made of blood interactions with plasticized poly(vinyl chloride) (PVC) biomaterials in tubular form, taking into account the influence on the blood response of the polymer, antithrombotic agent, blood condition and test procedure. In vitro and ex vivo procedures were used to achieve a comparison between PVC plasticized with di- (2-ethylhexyl)phthalate (DEHP) and with tri-(2-ethylhexyl)trimellitate (TEHTM). The blood response was monitored in terms of the measurement of fibrinogen adsorption capacity, thrombin–antithrombin III complex (TAT) and the complement component C3a. Surface characterization of the polymers was performed by X-ray photoelectron spectroscopy (XPS). The data obtained indicate that in comparison with DEHP-PVC, there is a higher reactivity for TEHTM-PVC, which correlates with the plasticizer distribution at the polymer surface. © 1999 Kluwer Academic Publishers

引用

页码：527 / 531

页数：4

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