Direct Inhibition and Down-regulation by Uremic Plasma Components of Hepatic Uptake Transporter for SN-38, an Active Metabolite of Irinotecan, in Humans

被引：0
|
作者：
Ken-ichi Fujita
Tomoko Sugiura
Hidenori Okumura
Saki Umeda
Noritaka Nakamichi
Yusuke Watanabe
Hiromichi Suzuki
Yu Sunakawa
Ken Shimada
Kaori Kawara
Yasutsuna Sasaki
Yukio Kato
机构：
[1] Saitama Medical University,Department of Medical Oncology, International Medical Center Comprehensive Cancer Center
[2] Kanazawa University,Faculty of Pharmacy Institute of Medical, Pharmaceutical and Health Sciences
[3] Saitama Medical University,Department of Nephrology
来源：
Pharmaceutical Research | 2014年 / 31卷
关键词：
human hepatocytes; organic anion transporting polypeptide; renal failure; SN-38; uremic toxins;
D O I：
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学科分类号：
摘要：
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页码：204 / 215
页数：11
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