Mammary Analogue Secretory Carcinoma: The First Submandibular Case Reported Including Findings on Fine Needle Aspiration Cytology

被引：49

作者：

Petersson F. ^{[1
]}

Lian D. ^{[2
]}

Chau Y.P. ^{[2
]}

Yan B. ^{[1
]}

机构：

[1] Department of Pathology, National University Health System, Singapore 119074

[2] Department of Pathology, Tan Tock Seng Hospital, Singapore

来源：

Head and Neck Pathology | 2012年 / 6卷 / 1期

关键词：

Carcinoma; Fine needle aspiration cytology; Salivary gland; Secretory carcinoma; Submandibular gland;

D O I：

10.1007/s12105-011-0283-x

中图分类号：

学科分类号：

摘要：

We present the first case (male, 35 years old) of a mammary analogue secretory carcinoma occurring in a submandibular gland and document findings on fine needle aspiration cytology. On histology, the tumor displayed characteristic features: circumscribed nodules composed of bland, pink to light red neoplastic cells with low proliferative/mitotic activity arranged in tubular, vaguely cribriform, and microcystic structures containing Periodic acid Schiff-positive, diastase-resistant secretory material. Immunohistochemistry showed strong and diffuse positivity for cytokeratin 7, S100 protein, and vimentin, as well as moderate to strong immunoreactivity for c-kit in the majority of tumor cells. A rearrangement of the ETV6 gene on fluorescence in situ hybridization was documented. The patient underwent an ipsilateral selective (levels I-IV) neck dissection which showed metastasis in 3 out of 36 lymph nodes (levels 1-3). Adjuvant radiotherapy was administered. No local recurrence or metastatic disease has been detected during a follow up period of 28 months. © 2011 Springer Science+Business Media, LLC.

引用

页码：135 / 139

页数：4

共 20 条

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