Successful allogeneic stem cell transplantation for an adult with refractory anaplastic lymphoma kinase—positive anaplastic large cell lymphoma

被引：0
作者：
Chao-Hsun Chen
Shan-Wen Chen
Wan-Lin Shen
Tsai-Yun Chen
Chao-Jung Tsao
Wen-Tsung Huang
机构：
[1] Chi-Mei Medical Center,Division of Hemato
[2] Chi- Mei Medical Center, oncology, Department of Internal Medicine
[3] National Cheng- Kung University Hospital,Department of Pathology
[4] National Cheng- Kung University,Division of Hemato
[5] Chi-Mei Medical Center, oncology, Department of Internal Medicine
[6] Liouying Campus,Institute of Clinical Medicine, College of Medicine
来源：
International Journal of Hematology | 2007年 / 85卷
关键词：
Anaplastic large cell lymphoma; Ki-1 lymphoma; ALK; Allogeneic stem cell transplantation;
D O I：
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中图分类号：
学科分类号：
摘要：
Anaplastic lymphoma kinase (ALK) expression exists in approximately 60% of anaplastic large cell lymphoma (ALCL) cases. Compared with the ALK-negative cases, ALK-positive cases are usually characterized by a good response to chemotherapy and a good prognosis. In the relapsed or refractory ALCL cases, high-dose chemotherapy followed by autologous stem cell transplantation has been widely used as a salvage therapy. However, 40% of patients who received transplants after more than 2 complete remissions eventually experienced disease progression, despite receiving autologous stem cell transplantation. Allogeneic stem cell transplantation has been proposed as a therapeutic option in refractory ALCL cases, but clinical reports of adult patients are rare. Herein, we report the case of an adult with refractory ALK-positive ALCL who was successfully treated with salvage high-dose chemotherapy followed by allogeneic stem cell transplantation.
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页码：105 / 107
页数：2
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