CRISPR/Cas9-edited ROS1 + non-small cell lung cancer cell lines highlight differential drug sensitivity in 2D vs 3D cultures while reflecting established resistance profiles

被引:0
作者
Marc Terrones
Christophe Deben
Felicia Rodrigues-Fortes
Anne Schepers
Ken Op de Beeck
Guy Van Camp
Geert Vandeweyer
机构
[1] University of Antwerp and Antwerp University Hospital,Center of Medical Genetics
[2] University of Antwerp and Antwerp University Hospital,Center for Oncological Research
来源
Journal of Translational Medicine | / 22卷
关键词
 + Non-small cell lung cancer; Tyrosine kinase inhibitors; CRISPR/Cas9; Drug resistance; 3D cell culture; 2D cell culture;
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