The Effect of Excipients on the Molecular Mobility of Lyophilized Formulations, as Measured by Glass Transition Temperature and NMR Relaxation-Based Critical Mobility Temperature

被引：0
作者：
Sumie Yoshioka
Yukio Aso
Shigeo Kojima
机构：
[1] National Institute of Health Sciences,
来源：
Pharmaceutical Research | 1999年 / 16卷
关键词：
lyophilized formulation; NMR relaxation; dielectric relaxation; molecular mobility; excipient;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. The dependence of the molecular mobility of lyophilized formulations on pharmaceutical polymer excipients was studied. Molecular mobility as determined by NMR relaxation-based critical temperature of molecular mobility (Tmc) and glass transition temperature (Tg) is discussed in relation to the plasticizing effect of water in formulations.
引用
收藏
页码：135 / 140
页数：5
相关论文
共 49 条
  • [21] Rickard E. C.(undefined)undefined undefined undefined undefined-undefined
  • [22] Maloney A. M.(undefined)undefined undefined undefined undefined-undefined
  • [23] Duddu S. P.(undefined)undefined undefined undefined undefined-undefined
  • [24] Dal Monte P. R.(undefined)undefined undefined undefined undefined-undefined
  • [25] Duddu S. P.(undefined)undefined undefined undefined undefined-undefined
  • [26] Zhang G.(undefined)undefined undefined undefined undefined-undefined
  • [27] Dal Monte P. R.(undefined)undefined undefined undefined undefined-undefined
  • [28] Yoshioka S.(undefined)undefined undefined undefined undefined-undefined
  • [29] Aso Y.(undefined)undefined undefined undefined undefined-undefined
  • [30] Kojima S.(undefined)undefined undefined undefined undefined-undefined
12345