The Effect of Excipients on the Molecular Mobility of Lyophilized Formulations, as Measured by Glass Transition Temperature and NMR Relaxation-Based Critical Mobility Temperature

被引：0
作者：
Sumie Yoshioka
Yukio Aso
Shigeo Kojima
机构：
[1] National Institute of Health Sciences,
来源：
Pharmaceutical Research | 1999年 / 16卷
关键词：
lyophilized formulation; NMR relaxation; dielectric relaxation; molecular mobility; excipient;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. The dependence of the molecular mobility of lyophilized formulations on pharmaceutical polymer excipients was studied. Molecular mobility as determined by NMR relaxation-based critical temperature of molecular mobility (Tmc) and glass transition temperature (Tg) is discussed in relation to the plasticizing effect of water in formulations.
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页码：135 / 140
页数：5
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  • [1] Hancock B. C.(1997)Characteristics and significance of the amorphous state in pharmaceutical systems J. Pharm. Sci. 86 1-12
  • [2] Zografi G.(1996)How does residual water affect the soid-state degradation of drugs in amorphous state J. Pharm. Sci. 85 1137-1140
  • [3] Shalaev E. Y.(1994)Crystallization of indomethacin from the amorphous state below and above its glass transition temperature J. Pharm. Sci. 83 1700-1705
  • [4] Zografi G.(1995)Inhibition of indomethacin crystallization in poly(vinylpyrrolidone) coprecipitates J. Pharm. Sci. 84 983-986
  • [5] Yoshioka M.(1995)Molecular mobility of amorphous pharmaceutical solids below their glass transition temperatures Pharm. Res. 12 799-806
  • [6] Hancock B. C.(1997)Molecular mobility of supercooled amorphus indomethacin, determined by dynamic mechanical analysis Pharm. Res. 14 410-414
  • [7] Zografi G.(1991)Formulation and stability of freeze-dried proteins: Effects of moisture and oxygen on the stability of freeze-dried formulations of human growth hormone Develop. Biol. Standard 74 21-38
  • [8] Yoshioka M.(1991)The effects of formulation and moisture on the stability of a freeze-dried monoclonal antibody-vinca conjugate: A test of the WLF glass transition theory Develop. Biol. Standard. 74 323-340
  • [9] Hancock B. C.(1997)Effect of glass transition temperature on the stability of lyophilized formulations containing a chimeric therapeutic monoclonal antibody Pharm. Res. 14 591-595
  • [10] Zografi G.(1997)The relationship between protein aggregation and molecular mobility below the glass transition temperature of lyophilized formulations containing a monoclonal antibody Pharm. Res. 14 596-600
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