Synthesis and study of organic nitrates of the heterofunctional series2. Synthesis and structure of 4,4-dihydroxymethyl-2-(3-pyridyl)-2-oxazoline dinitrate

The first representative of organic nitrates of the oxazoline series, 4,4-dihydroxymethyl-2-(3-pyridyl)-2-oxazoline dinitrate, was synthesized by the reaction ofN-nicotinoyltri(hydroxymethyl)aminomethane trinitrate hydronitrate (1) with a solution of KOH in alcohol. The reactivities of compound1 andN-nicotinoylethanolamine nitrate (nicorandil) in the reaction of intramolecular heterocyclization were compared. The structure of the compound synthesized has been established by X-ray diffraction analysis.