Using Animal Models to Understand Cancer Pain in Humans

被引：0
作者：
Gillian L. Currie
Emily S. Sena
Marie T. Fallon
Malcolm R. Macleod
Lesley A. Colvin
机构：
[1] University of Edinburgh,Department of Clinical Neurosciences, Chancellor’s Building
[2] University of Edinburgh,Edinburgh Cancer Research UK Centre
[3] Western General Hospital,Department of Anaesthesia, Critical Care and Pain Medicine
[4] Western General Hospital,Stroke Division
[5] Florey Institute of Neuroscience and Mental Health,undefined
来源：
Current Pain and Headache Reports | 2014年 / 18卷
关键词：
Cancer pain; Animal models; Neuropathic pain; Inflammation; Opioid treatment;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Cancer pain is not a single entity but a complex pain state involving different pain syndromes, with inflammatory, neuropathic, compressive, and ischaemic mechanisms. Current therapeutic regimens are based largely on opioids, although opioid treatment can lead to many side effects. Studies using animal models of cancer pain are aimed at understanding cancer pain and developing novel therapies. The most frequently reported models are of bone cancer pain, predominantly modelling pain associated with tumour growth within bone marrow. Here we summarise recent findings from studies using animal models of cancer pain and discuss the methodological quality of these studies.
引用
收藏
相关论文
共 238 条
[1]  
Grond S(1996)Assessment of cancer pain: a prospective evaluation in 2266 cancer patients referred to a pain service Pain 64 107-114
[2]  
Zech D(2013)Animal models of bone cancer pain: systematic review and meta-analyses Pain 154 917-926
[3]  
Diefenbach C(2013)A new rat model of bone cancer pain produced by rat breast cancer cells implantation of the shaft of femur at the third trochanter level Cancer Boil There 14 193-199
[4]  
Radbruch L(2011)Characterization of cancer-induced bone pain: an exploratory study Support Care Cancer 19 1393-1401
[5]  
Lehmann KA(2008)Clinical and pre-clinical pain assessment: are we measuring the same thing? Pain 135 7-10
[6]  
Currie GL(2012)The management of pain in metastatic bone disease Cancer Control 19 154-166
[7]  
Delaney A(2013)No need for translation when the same language is spoken Br J Anaesth 111 3-6
[8]  
Bennett MI(2013)Optimization and characterization of a rat model of prostate cancer-induced bone pain using behavioral, pharmacological, radiological, histological and immunohistochemical methods Pharmacol Biochem Behav. 106 33-46
[9]  
Dickenson AH(2006)A rat model of bone cancer pain induced by intra-tibia inoculation of Walker 256 mammary gland carcinoma cells Biochem Biophys Res Commun 345 1292-1298
[10]  
Egan KJ(2005)Behavioral characteristics of a mouse model of cancer pain Yonsei Med J 46 252-259
12345678910