Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas

被引：0
作者：
机构：
[1] St. Jude Children's Research Hospital,Department of Computational Biology
[2] St. Jude Children's Research Hospital,Department of Developmental Neurobiology
[3] St. Jude Children's Research Hospital,Department of Pathology
[4] St. Jude Children's Research Hospital,Department of Oncology
[5] St. Jude Children's Research Hospital,Department of Surgery
[6] The Genome Institute,Department of Genetics
[7] Washington University School of Medicine,Department of Structural Biology
[8] Washington University School of Medicine,undefined
[9] Pediatric Cancer Genome Project Laboratory,undefined
[10] St. Jude Children's Research Hospital,undefined
[11] Hartwell Center for Biotechnology & Bioinformatics,undefined
[12] St. Jude Children's Research Hospital,undefined
[13] St. Jude Children's Research Hospital,undefined
[14] Queen Mary University of London Centre for Neuroscience and Trauma,undefined
[15] The Blizard Institute,undefined
[16] Barts and the London School of Medicine and Dentistry,undefined
来源：
Nature Genetics | 2013年 / 45卷
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摘要：
David Ellison and colleagues report whole-genome sequencing of pediatric low-grade gliomas, the most common pediatric brain tumor. They identify a range of genomic alterations, including recurrent and mutually exclusive duplications of the FGFR1 region encoding the tyrosine kinase domain and rearrangements of MYB.
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页码：602 / 612
页数：10
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