Gender differences in lung cancer risk by smoking: A multicentre case-contral study in Germany and Italy

被引：0

作者：

Kreuzer M. ^{[1
,2
,10
]}

Boffetta P. ^{[3
]}

Whitley E. ^{[4
]}

Ahrens W. ^{[5
,6
]}

Gaborieau V. ^{[3
]}

Heinrich J. ^{[1
]}

Jöckel K.H ^{[6
]}

Kreienbrock L. ^{[1
]}

Mallone S. ^{[7
]}

Merletti F. ^{[8
]}

Roesch F. ^{[1
,3
]}

Zambon P. ^{[9
]}

Simonato L. ^{[9
]}

机构：

[1] GSF - Institute of Epidemiology, 85764 Neuherberg

[2] BfS - Inst. of Radiation Hygiene, 85764 Neuherberg

[3] IARC, Intl. Agy. for Res. on Cancer, 69372 Lyon Cedex 08, 150, Cours Albert-Thomas

[4] University of Bristol, Department of Social Medicine, Canynge Hall, Bristol BS8 2PR, Whiteladies Road

[5] Bremen Inst. for Prev. and Social M., 28199 Bremen

[6] University Clinics of Essen, Inst. for Med. Informatics, B., W. Ger. Cancer Center Essen (WTZE), 45122 Essen

[7] Epidemiology Unit Latium Region, 0198 Rome, Via di S Constanza

[8] Unit of Cancer Epidemiology, University of Turin, 10126 Turin, Via Santena

[9] Venetian Cancer Registry, 35128 Padua, Via Gattamelata

[10] Fed. Office of Radiation Protection, Institute of Radiation Hygiene, D-85764 Neuherberg

来源：

British Journal of Cancer | 2000年 / 82卷 / 1期

关键词：

Case-control study; Histology; Lung cancer; Smoking;

D O I：

10.1054/bjoc.1999.0904

中图分类号：

学科分类号：

摘要：

Several studies in the past have shown appreciably higher lung cancer risk estimates associated with smoking exposure among men than among women, while more recent studies in the USA report just the opposite. To evaluate this topic in a European population we conducted a case-control study of lung cancer in three German and three Italian centres. Personal interviews and standardized questionnaires were used to obtain detailed life-long smoking and occupational histories from 3723 male and 900 female cases and 4075 male and 1094 female controls. Lung cancer risk comparing ever-smokers with never-smokers was higher among men (odds ratios (OR) adjusted for age and centre = 16.1, 95% confidence intervai (CI) 12.8-20.3) than among women (OR = 4.2, CI 3.5-5.1). Because the smoking habits of women were different from men, we conducted more detailed analyses using comparable levels of smoking exposure. After restriction to smokers and adjustment for other smoking variables, risk estimates did not differ appreciably between genders. The analysis of duration of smoking (0-19, 20-39, 40+ years) adjusted for cigarette consumption and time since quitting smoking revealed similar risk estimates in men (OR = 1.0, 3.3 [CI 2.6-4.2], 4.1 [CI 3.1-5.6]) and women (OR = 1.0, 2.7 [CI 1.7-4.1], 3.3 [CI 1.9-5.8]). The same was true of the analysis of average or cumulative smoking consumption, and also of analyses stratified by different histological types. We conclude that for comparable exposure to tobacco smoke, the risk of lung cancer is comparable in women and men.

引用

页码：227 / 233

页数：6

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