Cardioprotective Effect of Modified Peroxiredoxins in Retrograde Perfusion of Isolated Rat Heart under Conditions of Oxidative Stress

被引：0
|
作者：
E. V. Karaduleva
E. K. Mubarakshina
M. G. Sharapov
A. E. Volkova
O. Yu. Pimenov
V. K. Ravin
Yu. M. Kokoz
V. I. Novoselov
机构：
[1] Russian Academy of Sciences,Institute of Cell Biophysics
[2] Russian Academy of Sciences,Institute of Theoretical and Experimental Biophysics
来源：
Bulletin of Experimental Biology and Medicine | 2016年 / 160卷
关键词：
oxidative stress; peroxiredoxins; retrograde perfusion of the heart;
D O I：
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学科分类号：
摘要：
Antioxidant properties of recombinant peroxiredoxin-6 and chimeric protein PSH combining peroxidase and superoxide dismutase activities were studied on the model of retrograde perfusion of isolated rat heart under conditions of H2O2-induced oxidative stress. The exogenous antioxidant proteins exhibited cardioprotective properties manifested in heart rate normalization, maintenance of contractile activity of the myocardium, and prevention of H2O2-induced LPO in oxidative stress. Localization of peroxiredoxin-6 and PSH in the cardiac tissue was determined and myocardial structures most effectively protected by the antioxidant enzymes from ischemia/reperfusion-induced damages were identified. The results suggest that modified peroxiredoxins are promising components of perfusion media for preservation of isolated organs.
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页码：639 / 642
页数：3
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