Role of Sonic Hedgehog (Shh) Signaling in Bladder Cancer Stemness and Tumorigenesis

被引：0
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作者：
Islam S. Syed
Akbari Pedram
Walid A. Farhat
机构：
[1] The Hospital for Sick Children,Developmental and Stem Cell Biology, Research Institute
[2] King Faisal Specialist Hospital and Research Centre,Cancer Biology and Experimental Therapeutic Section, Division of Molecular Oncology
来源：
Current Urology Reports | 2016年 / 17卷
关键词：
Sonic hedgehog signaling; Regenerative medicine; Bladder cancer;
D O I：
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学科分类号：
摘要：
Sonic hedgehog (Shh) signaling pathway has emerged as a critical component of bladder development, cancer initiation, and progression. While the role of Shh signaling in bladder development is well documented, its role in bladder cancer progression is uncertain. Additionally, epithelial-to-mesenchymal transition (EMT) has been identified to promote bladder cancer progression in the initial stages and also contribute to drug resistance in the later stage and ultimately metastasis. We speculate that epithelial-to-mesenchymal transitions (EMT) and Shh fuel the carcinogenesis process. This review presents the most recent studies focusing on the role of Shh signaling in bladder cancer progression
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