Development of sarcoidosis in etanercept-treated rheumatoid arthritis patients

被引：0
作者：
Kilian Verschueren
Els Van Essche
Patrick Verschueren
Veerle Taelman
Rene Westhovens
机构：
[1] Katholieke Universiteit Leuven,Department of Rheumatology, University Hospitals Leuven
[2] Rheumatology Mol,undefined
[3] Universitair Ziekenhuis Leuven,undefined
来源：
Clinical Rheumatology | 2007年 / 26卷
关键词：
Etanercept; Granuloma; Infliximab; Rheumatoid arthritis; Sarcoidosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We report two rheumatoid arthritis patients developing sarcoidosis possibly induced by etanercept. Both women, aged 46 and 53, had erosive, rheumatoid-factor-positive rheumatoid arthritis (RA) for 7 and 6 years, respectively. The eldest had received infliximab for over a year with good response, which was stopped because of a perfusion reaction. She developed a cough and dyspnea after 6 months of etanercept treatment. The other developed erythema nodosum and a plaque lesion on the right arm after 1 year of etanercept. Imaging showed, in both cases, mediastinal adenopathies. Biopsies were compatible with sarcoidosis. Etanercept withdrawal led to a complete remission. Recently, there have been reports of noninfectious granulomatous syndromes in patients receiving etanercept for a variety of diseases. In our cases, the temporal association with etanercept therapy and the complete remission after suspension of etanercept suggest a triggering role of this agent. Possible mechanisms of action and supporting evidence are discussed.
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页码：1969 / 1971
页数：2
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