X-ray structure of a prokaryotic pentameric ligand-gated ion channel

被引：0
|
作者：
Ricarda J. C. Hilf
Raimund Dutzler
机构：
[1] University of Zürich,Department of Biochemistry
[2] Winterthurer Strasse 190,undefined
[3] CH-8057 Zürich,undefined
[4] Switzerland,undefined
来源：
Nature | 2008年 / 452卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The X-ray structure of a prokaryotic pentameric ligand-gated ion channels (pLGIC) from the bacterium Erwinia chrysanthemi (ELIC) at 3.3 Å resolution is presented. This study reveals the first structure of a pLGIC at high resolution and provides an important model system for the investigation of the general mechanisms of ion permeation and gating within the family.
引用
收藏
页码：375 / 379
页数：4
相关论文
共 50 条
  • [1] X-ray structure of a prokaryotic pentameric ligand-gated ion channel
    Hilf, Ricarda J. C.
    Dutzler, Raimund
    NATURE, 2008, 452 (7185) : 375 - U12
  • [2] A prokaryotic perspective on pentameric ligand-gated ion channel structure
    Hilf, Ricarda J. C.
    Dutzler, Raimund
    CURRENT OPINION IN STRUCTURAL BIOLOGY, 2009, 19 (04) : 418 - 424
  • [3] X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation
    Bocquet, Nicolas
    Nury, Hugues
    Baaden, Marc
    Le Poupon, Chantal
    Changeux, Jean-Pierre
    Delarue, Marc
    Corringer, Pierre-Jean
    NATURE, 2009, 457 (7225) : 111 - 114
  • [4] X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation
    Nicolas Bocquet
    Hugues Nury
    Marc Baaden
    Chantal Le Poupon
    Jean-Pierre Changeux
    Marc Delarue
    Pierre-Jean Corringer
    Nature, 2009, 457 : 111 - 114
  • [5] A Prokaryotic Perspective on Pentameric Ligand-Gated Ion Channel Structure and Function
    Dutzler, Raimund
    BIOPHYSICAL JOURNAL, 2012, 102 (03) : 417A - 417A
  • [6] Ligand Activation of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC
    Zimmermann, Iwan
    Dutzler, Raimund
    PLOS BIOLOGY, 2011, 9 (06)
  • [7] X-Ray Structures of General Anaesthetics Bound to a Pentameric Ligand-Gated Ion Channel
    Nury, Hugues
    Van Renterghem, Catherine
    Weng, Yun
    Tran, Alfonso
    Baaden, Marc
    Dufresne, Virginie
    Changeux, Jean-Pierre
    Sonner, Jim
    Delarue, Marc
    Corringer, Pierre-Jean
    BIOPHYSICAL JOURNAL, 2012, 102 (03) : 119A - 119A
  • [8] X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel
    Hugues Nury
    Catherine Van Renterghem
    Yun Weng
    Alphonso Tran
    Marc Baaden
    Virginie Dufresne
    Jean-Pierre Changeux
    James M. Sonner
    Marc Delarue
    Pierre-Jean Corringer
    Nature, 2011, 469 : 428 - 431
  • [9] X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel
    Nury, Hugues
    Van Renterghem, Catherine
    Weng, Yun
    Tran, Alphonso
    Baaden, Marc
    Dufresne, Virginie
    Changeux, Jean-Pierre
    Sonner, James M.
    Delarue, Marc
    Corringer, Pierre-Jean
    NATURE, 2011, 469 (7330) : 428 - +
  • [10] Mutational Analysis of the Prokaryotic Pentameric Ligand-Gated Ion Channel GLIC
    Ghosh, Borna
    Hanson, Susan
    Czajkowski, Cynthia
    BIOPHYSICAL JOURNAL, 2010, 98 (03) : 703A - 703A
12345