In vitro microsomal metabolism of nuclear chloro substituted secondary amines and imines

被引：0

作者：

I. Küçükgüzel

M. Ülgen

J. W. Gorrod

机构：

[1] Marmara University,Department of Pharmaceutical Chemistry, Faculty of Pharmacy

[2] University of London,Chelsea Department of Pharmacy, King’s College London

[3] University of Essex,The Toxicology Unit, John Tabor Laboratories

来源：

European Journal of Drug Metabolism and Pharmacokinetics | 1997年 / 22卷 / 4期

关键词：

Secondary amines; hydroxylamines; nitrones; oxaziridines; metabolism;

D O I：

10.1007/BF03190970

中图分类号：

学科分类号：

摘要：

The metabolism of N-(4-chlorobenzyl)-4-chloroaniline (CBCA), N-(4-chlorobenzyl)-4-chlorobenzylamine (CBCBA), and N-(4-chlorobenzylidene)-4-chlorobenzylamine (CBDCBA) were studied in vitro using rat liver microsomal preparations. The secondary amines produced the corresponding N-oxidation products (hydroxylamines and nitrones) and dealkylation products (4-chlorobenzaldehyde and primary amines). Both secondary amines failed to produce the corresponding amides, whilst the parent imine was detected as a metabonate. CBDCBA, the intermediate imine of CBCBA metabolism, was also incubated under similar conditions. However, no oxaziridine was detected.

引用

页码：351 / 358

页数：7

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