PGE2 promotes renal carcinoma cell invasion through activated RalA

被引：0
作者：
Z Li
Y Zhang
W J Kim
Y Daaka
机构：
[1] University of Florida College of Medicine,Department of Urology and Prostate Disease Center
[2] University of Florida College of Medicine,Department of Anatomy and Cell Biology
来源：
Oncogene | 2013年 / 32卷
关键词：
renal cell carcinoma; cell invasion; inflammation; PGE2; Ral;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Incidence of kidney cancer is on the rise, and a better understanding of molecular mechanisms involved in the cancer invasion and metastasis is required for the development of curative therapeutics. In this study, we report that the proinflammatory cytokine prostaglandin E2 (PGE2) induces the malignant SN12C, but not benign HK2 kidney cell invasion. The PGE2 increases SN12C cell invasion through a signal pathway that encompasses EP2 and EP4, Akt, small GTPase RalA and Ral·GTP inactivator RGC2. The results support the idea that targeted interference of EP2/EP4 signal to RalA·GTP may provide benefit to patients diagnosed with advanced kidney cancer.
引用
收藏
页码：1408 / 1415
页数：7
相关论文
共 136 条
[1]  
Siegel R(2011)The impact of eliminating socioeconomic and racial disparities on premature cancer deaths CA Cancer J Clin 61 212-236
[2]  
Ward E(2006)Current trends in molecular classification of adult renal tumors Urology 67 873-880
[3]  
Brawley O(2010)Treatment of metastatic renal cell carcinoma Nat Rev Urol 7 327-338
[4]  
Jemal A(2009)Immunotherapeutic strategies in kidney cancer - when TKIs are not enough Nat Rev Clin Oncol 6 478-487
[5]  
Young AN(2008)Metastatic renal cell carcinoma: Results of a population-based study with 25 years follow-up Eur J Cancer 44 2485-2495
[6]  
Dale J(2004)Renal cell carcinoma: Etiology, incidence and epidemiology Curr Opin Urol 14 229-233
[7]  
Yin-Goen QQ(2010)Cancer and inflammation: Implications for pharmacology and therapeutics Clin Pharmacol Therap 87 401-406
[8]  
Harris WB(2010)Immunity, inflammation, and cancer Cell 140 883-899
[9]  
Petros JA(2011)Aberrant PGE2 metabolism in bladder tumor microenvironment promotes immunosuppressive phenotype of tumor-infiltrating myeloid cells Int Immunopharmacol 11 848-855
[10]  
Datta MW(2008)Physiological regulation of prostaglandins in the kidney Ann Rev Physiol 70 357-377
12345678910