Vascular permeability in ocular disease and the role of tight junctions

被引：165
作者：
Erickson K.K. [1 ]
Sundstrom J.M. [1 ]
Antonetti D.A. [1 ]
机构：
[1] Department of Cellular and Molecular Physiology, Penn. State College of Medicine, Hershey
来源：
Angiogenesis | 2007年 / 10卷 / 2期
基金：
美国国家卫生研究院;
关键词：
Blood retinal barrier; Claudin; Occludin; Permeability; Tight junctions; Zonula occludens;
D O I：
10.1007/s10456-007-9067-z
中图分类号：
学科分类号：
摘要：
Vascular permeability is closely linked with angiogenesis in a number of pathologies. In the retina, the normally well-developed blood-retinal barrier is altered in a host of eye diseases preceding or commensurate with angiogenesis. This review examines the literature regarding the tight junction complex that establishes the blood-retinal barrier focusing on the transmembrane proteins occludin and the claudin family and the membrane associated protein zonula occludens. The changes observed in these proteins associated with vascular and epithelial permeability is discussed. Finally, novel literature addressing the link between the tight junction complex and angiogenesis is considered. © 2007 Springer Science + Business Media B.V.
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收藏
页码：103 / 117
页数：14
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